ventilation

The Role of Mechanical Ventilation in ARF Management

by ICU Ventilator

Mechanical ventilation plays a critical role in addressing the pathophysiological mechanisms underlying acute respiratory failure (ARF). By correcting gas exchange abnormalities, reducing respiratory muscle workload, and preventing complications, it provides essential support for patients in critical conditions (1,5,7,8). Below, specific mechanisms of mechanical ventilation are linked to the pathophysiological issues they target to enhance clarity and coherence.

Correction of Hypoxemia

One of the primary goals of mechanical ventilation in ARF is to address hypoxemia caused by mechanisms such as ventilation-perfusion (V/Q) mismatch, shunting, or diffusion impairment.

  • Mechanism: Mechanical ventilation increases the fraction of inspired oxygen (FiO₂), ensuring higher oxygen availability in the alveoli, which is crucial for patients with reduced oxygenation due to pneumonia, ARDS, or pulmonary embolism.
  • PEEP (Positive End-Expiratory Pressure): PEEP prevents alveolar collapse during exhalation by maintaining positive pressure in the lungs, thereby improving functional residual capacity (FRC). This is particularly effective in conditions involving alveolar instability, such as ARDS or atelectasis.
  • Link to Pathophysiology: In cases of shunting, where blood bypasses ventilated alveoli, PEEP recruits collapsed alveoli and redistributes ventilation, reducing hypoxemia.

Removal of Hypercapnia

Hypercapnia in ARF arises from hypoventilation or increased dead space, as seen in conditions like COPD exacerbations or severe obesity hypoventilation syndrome.

  • Mechanism: Mechanical ventilation increases minute ventilation by optimizing tidal volume (VT) and respiratory rate. By enhancing the removal of carbon dioxide, it normalizes arterial pH and relieves respiratory acidosis.
  • Pressure-Control Ventilation (PCV): PCV is particularly beneficial in hypercapnic ARF as it delivers preset pressure during inspiration, ensuring adequate ventilation while minimizing airway pressures.
  • Link to Pathophysiology: In hypoventilation-related hypercapnia, increasing ventilatory support reduces carbon dioxide retention, reversing acidemia and preventing hemodynamic instability.

Reduction of Work of Breathing

ARF often places a high workload on respiratory muscles, leading to fatigue and eventual failure, especially in conditions like COPD exacerbations or severe asthma.

  • Mechanism: Mechanical ventilation reduces the effort required to breathe by delivering positive pressure during inspiration. Modes like pressure support ventilation (PSV) and assist-control ventilation (ACV) enable respiratory muscle rest while maintaining adequate ventilation.
  • Link to Pathophysiology: By decreasing the work of breathing, mechanical ventilation prevents respiratory muscle exhaustion, a key contributor to hypercapnic ARF.

Alveolar Recruitment and Stabilization

Alveolar recruitment strategies are critical for restoring effective gas exchange in conditions like ARDS, where alveolar collapse and severe V/Q mismatch are common.

  • Mechanism: PEEP and lung-protective ventilation strategies, such as low tidal volumes, recruit and stabilize alveoli, increasing the surface area available for gas exchange.
  • Link to Pathophysiology: In ARDS, where alveolar collapse exacerbates shunting, PEEP opens collapsed alveoli, improving oxygenation and reducing the severity of hypoxemia.

Prevention of Secondary Complications

Mechanical ventilation provides controlled respiratory support that reduces the risk of secondary complications such as aspiration, ventilator-associated pneumonia (VAP), or multi-organ failure.

  • Mechanism: Secure airway management with invasive mechanical ventilation protects against aspiration, while precise ventilator settings minimize barotrauma and ventilator-induced lung injury (VILI).
  • Link to Pathophysiology: By addressing hypoxemia and hypercapnia, mechanical ventilation prevents systemic complications like hypoxia-induced multi-organ failure and maintains hemodynamic stability.

Mechanical ventilation compensates for the physiological disruptions seen in ARF by targeting specific mechanisms like V/Q mismatch, diffusion impairment, and increased work of breathing. Each intervention, whether optimizing oxygenation, reducing carbon dioxide levels, or stabilizing alveolar function, is tailored to the patient’s underlying pathology.

This ensures effective management of ARF while minimizing complications, emphasizing the indispensable role of mechanical ventilation in critical care settings (1-8,10).

Types of Mechanical Ventilation

Mechanical ventilation is classified into invasive and non-invasive methods, each with specific applications based on the patient’s condition and therapeutic needs (9-11). Both types play a vital role in the management of acute respiratory failure (ARF), with the choice determined by the severity of respiratory dysfunction and the clinical response to treatment (10).

Non-Invasive Ventilation (NIV)

Non-invasive ventilation delivers respiratory support through a mask or nasal interface, avoiding the need for intubation. It is particularly effective in patients with mild to moderate ARF who are conscious and able to protect their airway.

  • Mechanism: NIV enhances oxygenation and ventilation using positive airway pressure, which prevents alveolar collapse and reduces the work of breathing.
  • Common Modes:
    • Continuous Positive Airway Pressure (CPAP): Maintains constant positive airway pressure throughout the respiratory cycle, improving oxygenation in conditions such as cardiogenic pulmonary edema.
    • Bilevel Positive Airway Pressure (BiPAP): Alternates between inspiratory positive airway pressure (IPAP) and expiratory positive airway pressure (EPAP), facilitating both oxygenation and ventilation, particularly in hypercapnic ARF seen in COPD exacerbations.
  • Clinical Application: NIV is widely used in exacerbations of chronic conditions like COPD, mild ARDS, and heart failure, where it can stabilize gas exchange and reduce the need for intubation.

Invasive Mechanical Ventilation (IMV)

In cases where non-invasive ventilation fails to stabilize ARF or is contraindicated, invasive mechanical ventilation provides controlled respiratory support through an endotracheal or tracheostomy tube.

  • Mechanism: IMV directly accesses the airway, ensuring precise delivery of oxygen, removal of carbon dioxide, and reduction of respiratory muscle workload. It also facilitates better protection against aspiration in patients with altered mental status or significant secretions.
  • Common Modes:
    • Assist-Control Ventilation (ACV): Delivers a preset tidal volume or pressure with every breath, whether initiated by the patient or the ventilator. ACV provides full respiratory support, ideal for patients with severe ARF and minimal respiratory effort.
    • Synchronized Intermittent Mandatory Ventilation (SIMV): Combines mandatory ventilator-delivered breaths with the patient’s spontaneous breaths. It is frequently used during weaning to encourage respiratory muscle activity.
    • Pressure Support Ventilation (PSV): Supports spontaneous breathing by delivering a set inspiratory pressure. It is commonly employed during recovery or as a step-down mode in the weaning process.
  • Clinical Application: IMV is indicated in severe ARF with refractory hypoxemia, hypercapnia unresponsive to NIV, or conditions like ARDS, where invasive strategies like lung-protective ventilation and high PEEP are essential.

Non-invasive ventilation often serves as the first-line treatment in ARF. However, in some cases, such as persistent hypoxemia, rising carbon dioxide levels, or respiratory distress that worsens despite NIV, transitioning to invasive mechanical ventilation becomes necessary to ensure adequate respiratory support and prevent further deterioration (9–11). The specific criteria and clinical scenarios guiding this transition will be examined in a subsequent section.

By tailoring the type of mechanical ventilation to the patient’s condition and response, clinicians can optimize outcomes while minimizing complications.

Modes of Mechanical Ventilation for ARF Treatment

The choice of mechanical ventilation mode in acute respiratory failure (ARF) is determined by the underlying pathology, severity of respiratory compromise, and patient-specific factors (11,12). Optimizing the mode of ventilation is essential to ensure adequate gas exchange while minimizing complications (12). Below, the most commonly used modes are outlined, with an emphasis on their applications and clinical significance.

Assist-Control Ventilation (ACV)

ACV provides full respiratory support by delivering a preset tidal volume (VT) or pressure with each breath, regardless of whether the breath is initiated by the patient or the ventilator.

  • Application: This mode is typically used in severe ARF, particularly in conditions such as ARDS or pneumonia, where patients may have minimal or absent spontaneous respiratory effort.
  • Advantages: Guarantees consistent ventilation and simplifies management in critically ill patients.

Synchronized Intermittent Mandatory Ventilation (SIMV)

SIMV delivers a set number of mandatory breaths, synchronized with the patient’s spontaneous respiratory efforts, allowing for unassisted breaths in between.

  • Application: Often employed as an intermediate step in patients transitioning from full ventilatory support to spontaneous breathing, such as during the weaning process.
  • Advantages: Promotes respiratory muscle activity while providing a safety net of mandatory ventilator breaths.

Pressure Support Ventilation (PSV)

PSV augments spontaneous breathing by providing a preset level of inspiratory pressure, reducing the effort required for inspiration.

  • Application: Commonly used in patients with preserved respiratory drive, such as those recovering from ARF or during non-invasive ventilation (NIV).
  • Advantages: Improves patient comfort, reduces work of breathing, and facilitates weaning from invasive ventilation.

Volume-Controlled and Pressure-Controlled Ventilation (VCV/PCV)

  • Volume-Controlled Ventilation (VCV) delivers a preset tidal volume, with airway pressure varying depending on lung compliance and resistance.

    Application: Used in patients requiring precise control of minute ventilation, such as those with hypercapnia.
  • Pressure-Controlled Ventilation (PCV) delivers a preset pressure during inspiration, with tidal volume varying based on lung compliance.

    Application: Beneficial in patients with reduced lung compliance, such as in ARDS, to limit peak airway pressures and reduce the risk of barotrauma.

High-Frequency Oscillatory Ventilation (HFOV)

HFOV delivers very small tidal volumes at high frequencies, maintaining continuous positive airway pressure.

  • Application: A rescue strategy for refractory hypoxemia in ARDS when conventional ventilation fails.
  • Advantages: Minimizes ventilator-induced lung injury (VILI) by preventing alveolar overdistension.

Clinical Significance

The selection of the appropriate mode of mechanical ventilation in ARF is crucial for optimizing outcomes and minimizing complications. For instance, lung-protective ventilation strategies, such as low tidal volume ventilation in ARDS, reduce the risk of ventilator-induced lung injury (11).
Modes like SIMV and PSV play key roles in facilitating weaning and restoring spontaneous respiratory function (11). By tailoring ventilation modes to the individual needs of patients, clinicians can address the specific pathophysiological challenges of ARF while improving survival and recovery rates (11-15).

Advanced Modes of Mechanical Ventilation: ASV, SAV, and NAVA

With the evolution of mechanical ventilation, advanced modes like Adaptive Support Ventilation (ASV), SmartCare/Automated Ventilation (SAV), and Neurally Adjusted Ventilatory Assist (NAVA) have emerged as pivotal tools in modern respiratory care. These modes leverage intelligent algorithms and neural control mechanisms to enhance patient outcomes, improve synchronization, and simplify clinical workflows. Below is a comprehensive discussion of each mode and its clinical significance (23-25).

Adaptive Support Ventilation (ASV)

  • What is ASV?
     ASV is an intelligent mode of mechanical ventilation that automatically adjusts ventilatory support based on the patient’s respiratory mechanics and effort. It uses algorithms to calculate the ideal tidal volume and respiratory rate based on the patient’s predicted body weight, lung compliance, and airway resistance (22-25).
  • How ASV Works:
    • ASV continuously monitors the patient’s spontaneous breathing.
    • It dynamically adjusts the inspiratory pressure and ventilatory rate to meet the patient’s metabolic demand while preventing over-distension or atelectasis.
    • This mode ensures minimal work of breathing while maintaining target minute ventilation.
  • Benefits of ASV:
    • Automatically reduces support as the patient’s respiratory effort improves, facilitating a smooth transition from controlled to spontaneous breathing.
    • Decreases the risk of hyperventilation, barotrauma, and ventilator-induced lung injury (VILI) (23,24).
    • Improves patient-ventilator synchrony, reducing discomfort and sedation requirements (24).
  • Evidence and Clinical Applications:
    • Studies have shown ASV to be effective in both acute and chronic respiratory failure. For example, research published in Critical Care (Arnal et al., 2008) demonstrated that ASV reduced ventilation duration compared to traditional modes in post-operative ICU patients (26).
    • It is widely used in settings requiring dynamic adaptation, such as weaning and managing variable lung mechanics in conditions like ARDS or COPD exacerbations (27).

SmartCare/Automated Ventilation (SAV)

  • What is SAV?
     SmartCare/Automated Ventilation is a closed-loop ventilation system designed primarily to automate the weaning process. It uses an artificial intelligence algorithm to assess and adjust ventilatory support based on real-time patient parameters (25,28-31).
  • How SAV Works:
    • SAV continuously monitors the patient’s respiratory rate, tidal volume, and end-tidal carbon dioxide (EtCO₂).
    • Based on these parameters, it adjusts pressure support levels to ensure adequate ventilation and oxygenation.
    • When the algorithm determines that the patient can sustain spontaneous breathing, it suggests readiness for extubation.
  • Benefits of SAV:
    • Speeds up the weaning process by reducing the need for manual adjustments (22-31).
    • Prevents premature or delayed extubation by following evidence-based criteria.
    • Reduces the workload for ICU staff and standardizes the weaning process.
  • Evidence and Clinical Applications:
    • Clinical trials, such as those published in Intensive Care Medicine (Lellouche et al., 2006), have shown that SmartCare reduces the duration of mechanical ventilation and ICU stay while improving extubation success rates (31).
    • SAV is especially useful in ICUs with high patient volumes or variability in care protocols (24-31).

Neurally Adjusted Ventilatory Assist (NAVA)

  • What is NAVA
    Neurally Adjusted Ventilatory Assist (NAVA) is an advanced mode of mechanical ventilation that directly uses the patient’s neural respiratory drive to control ventilatory support. Unlike traditional modes that rely on airway pressure or flow triggers, NAVA is driven by electrical activity in the diaphragm (Edi), offering highly personalized and precise ventilation (25-34).
  • How NAVA Works?

    Edi Catheter:
    A specialized nasogastric catheter detects electrical signals from the diaphragm during the patient’s spontaneous breathing efforts.

    Signal Processing:
    These signals (Edi) are analyzed in real-time to determine the timing, duration, and intensity of inspiratory effort.

    Ventilator Response:
    The ventilator delivers pressure support proportional to the patient’s effort, ensuring optimal synchronization and avoiding over-assistance or under-assistance.
  • Advantages of NAVA

    Improved Patient-Ventilator Synchrony:
    NAVA directly responds to the patient’s neural respiratory signals, eliminating delays and mismatches that occur with pressure or flow triggering.
    Reduces asynchrony-related complications, such as ineffective efforts, double triggering, and patient discomfort.

    Reduction in Sedation Needs:
    By providing natural, synchronized support, NAVA minimizes the discomfort associated with mechanical ventilation, reducing the need for sedatives.

    Enhanced Respiratory Muscle Protection:
    Unlike traditional modes that can over-assist, leading to respiratory muscle atrophy, NAVA ensures the diaphragm remains active, maintaining muscle strength and endurance.

    Personalized Ventilation:
    Adapts dynamically to the patient’s changing respiratory demands, particularly in conditions like ARDS, COPD, or neuromuscular disorders.
  • Clinical Applications of NAVA

    ARDS and Acute Respiratory Failure (ARF):
    NAVA provides lung-protective ventilation by avoiding overdistension and barotrauma while maintaining synchrony (38).

    Neonatal and Pediatric Ventilation:
    Especially useful in premature infants and pediatric patients, where synchrony challenges are common with traditional modes (36-37,39-43).

    Weaning:
    Facilitates a gradual reduction in ventilatory support by responding to the patient’s natural efforts (44-45).

    NAVA represents a significant advancement in mechanical ventilation, focusing on precision and patient-centric care by using the diaphragm’s electrical activity to guide support. Its ability to enhance patient-ventilator synchrony, reduce sedation needs, and protect respiratory muscles makes it an invaluable mode in both adult and pediatric populations. When combined with other modes like ASV and SAV, NAVA provides a versatile and comprehensive approach to managing acute respiratory failure.

When to Transition from Non-Invasive Mechanical Ventilation (NIMV) to Invasive Mechanical Ventilation (IMV) in ARF

Non-invasive mechanical ventilation (NIMV) is often the first-line treatment for acute respiratory failure (ARF) in specific conditions like COPD exacerbations or mild-to-moderate hypoxemia. However, in some cases, NIMV may fail to provide adequate support, requiring a transition to invasive mechanical ventilation (IMV) to prevent further deterioration. Here are the key indicators and clinical scenarios to consider transitioning:

1. Worsening Gas Exchange Despite NIMV

  • Signs:
    • Persistent or worsening hypoxemia (PaO₂ < 60 mmHg on FiO₂ ≥ 0.6).
    • Rising PaCO₂ (> 50 mmHg) with associated respiratory acidosis (pH < 7.25).
  • Reason: Indicates that NIMV is insufficient to meet oxygenation or ventilation demands.

2. Severe Respiratory Distress

  • Signs:
    • Increased respiratory rate (> 35 breaths/min).
    • Use of accessory muscles, paradoxical breathing, or nasal flaring.
    • Inability to speak in full sentences due to dyspnea.
  • Reason: Suggests that the patient’s work of breathing has exceeded the support provided by NIMV, risking respiratory muscle fatigue and collapse.

3. Altered Mental Status

  • Signs:
    • Confusion, agitation, or inability to cooperate with NIMV.
    • Progression to somnolence or coma (indicating hypercapnia or hypoxemia affecting cerebral function).
  • Reason: Neurological impairment reduces the ability to maintain spontaneous breathing or adhere to NIMV.

4. Hemodynamic Instability

  • Signs:
    • Hypotension (systolic blood pressure < 90 mmHg) unresponsive to fluid resuscitation.
    • Shock or signs of reduced cardiac output.
  • Reason: Indicates systemic compromise that requires better oxygenation and ventilation control via IMV.

5. Risk of Aspiration or Airway Protection Issues

  • Signs:
    • Inability to clear secretions or significant mucus plugging.
    • Frequent vomiting or risk of aspiration (e.g., altered consciousness).
  • Reason: IMV is necessary to secure the airway with an endotracheal tube to prevent aspiration-related complications.

6. Failure to Tolerate NIMV

  • Signs:
    • Poor mask seal due to facial anatomy or agitation.
    • Skin breakdown or discomfort causing discontinuation of therapy.
  • Reason: Intolerance to NIMV can reduce adherence, rendering it ineffective.

7. No Clinical Improvement Within 1–2 Hours of NIMV

  • Signs:
    • Lack of improvement in respiratory rate, gas exchange, or oxygenation after 1–2 hours of optimal NIMV.
  • Reason: Delaying the switch to IMV increases the risk of respiratory arrest and worsens outcomes.

The decision to switch from NIMV to IMV in ARF should be guided by clinical judgment, monitoring of gas exchange, respiratory mechanics, and overall patient stability. Early recognition of NIMV failure and timely intubation improve outcomes and prevent complications associated with delayed intervention (12-14, 16-21).

References

  1. Kapil S, Wilson JG. Mechanical Ventilation in Hypoxemic Respiratory Failure. Emerg Med Clin North Am. 2019;37(3):431-444. doi:10.1016/j.emc.2019.04.005
  2. Delerme S, Ray P. Acute respiratory failure in the elderly: diagnosis and prognosis. Age Ageing. 2008;37(3):251-257. doi:10.1093/ageing/afn060
  3. Antro C, Merico F, Urbino R, Gai V. Non-invasive ventilation as a first-line treatment for acute respiratory failure: “real life” experience in the emergency department. Emerg Med J. 2005;22(11):772-777. doi:10.1136/emj.2004.018309
  4. Piraino T. Noninvasive Respiratory Support in Acute Hypoxemic Respiratory Failure. Respir Care. 2019;64(6):638-646. doi:10.4187/respcare.06735
  5. Abellan C, Bertin C, Fumeaux T, Carrel L. Insuffisance respiratoire aiguë : prise en charge hospitalière non invasive [Acute respiratory failure : non-invasive hospital management]. Rev Med Suisse. 2020;16(705):1636-1644.
  6. Munshi L, Mancebo J, Brochard LJ. Noninvasive Respiratory Support for Adults with Acute Respiratory Failure. N Engl J Med. 2022;387(18):1688-1698. doi:10.1056/NEJMra2204556
  7. Pisani L, Corcione N, Nava S. Management of acute hypercapnic respiratory failure. Curr Opin Crit Care. 2016;22(1):45-52. doi:10.1097/MCC.0000000000000269
  8. Liu YJ, Zhao J, Tang H. Non-invasive ventilation in acute respiratory failure: a meta-analysis. Clin Med (Lond). 2016;16(6):514-523. doi:10.7861/clinmedicine.16-6-514
  9. Pham T, Brochard LJ, Slutsky AS. Mechanical Ventilation: State of the Art. Mayo Clin Proc. 2017;92(9):1382-1400. doi:10.1016/j.mayocp.2017.05.004
  10. Tobin MJ, Laghi F, Jubran A. Ventilatory failure, ventilator support, and ventilator weaning. Compr Physiol. 2012;2(4):2871-2921. doi:10.1002/cphy.c110030
  11. Tobin, M. J. (2013). Principles and practice of mechanical ventilation, 3e. McGraw-Hill Education LLC.
  12. Pinsky MR. Toward a better ventilation strategy for patients with acute lung injury. Crit Care. 2000;4(4):205-206. doi:10.1186/cc695
  13. Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017;50(2):1602426. Published 2017 Aug 31. doi:10.1183/13993003.02426-2016
  14. Torres A, Niederman MS, Chastre J, et al. International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia: Guidelines for the management of hospital-acquired pneumonia (HAP)/ventilator-associated pneumonia (VAP) of the European Respiratory Society (ERS), European Society of Intensive Care Medicine (ESICM), European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and Asociación Latinoamericana del Tórax (ALAT). Eur Respir J. 2017;50(3):1700582. Published 2017 Sep 10. doi:10.1183/13993003.00582-2017
  15. Oczkowski S, Ergan B, Bos L, et al. ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure. Eur Respir J. 2022;59(4):2101574. Published 2022 Apr 14. doi:10.1183/13993003.01574-2021
  16. Luo F, Annane D, Orlikowski D, et al. Invasive versus non-invasive ventilation for acute respiratory failure in neuromuscular disease and chest wall disorders. Cochrane Database Syst Rev. 2017;12(12):CD008380. Published 2017 Dec 4. doi:10.1002/14651858.CD008380.pub2
  17. Blumenthal JA, Duvall MG. Invasive and noninvasive ventilation strategies for acute respiratory failure in children with coronavirus disease 2019. Curr Opin Pediatr. 2021;33(3):311-318. doi:10.1097/MOP.0000000000001021
  18. Shang P, Zhu M, Baker M, Feng J, Zhou C, Zhang HL. Mechanical ventilation in Guillain-Barré syndrome. Expert Rev Clin Immunol. 2020;16(11):1053-1064. doi:10.1080/1744666X.2021.1840355
  19. Davidson AC, Banham S, Elliott M, et al. BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults [published correction appears in Thorax. 2017 Jun;72(6):588. doi: 10.1136/thoraxjnl-2015-208209corr1]. Thorax. 2016;71 Suppl 2:ii1-ii35. doi:10.1136/thoraxjnl-2015-208209      
  20. Kress JP, O’Connor MF, Schmidt GA. Clinical examination reliably detects intrinsic positive end-expiratory pressure in critically ill, mechanically ventilated patients. Am J Respir Crit Care Med. 1999;159(1):290-294. doi:10.1164/ajrccm.159.1.9805011
  21. Rittayamai N, Katsios CM, Beloncle F, Friedrich JO, Mancebo J, Brochard L. Pressure-Controlled vs Volume-Controlled Ventilation in Acute Respiratory Failure: A Physiology-Based Narrative and Systematic Review. Chest. 2015;148(2):340-355. doi:10.1378/chest.14-3169
  22. Brunner JX, Iotti GA. Adaptive Support Ventilation (ASV). Minerva Anestesiol. 2002;68(5):365-368.
  23. Dai YL, Hsu RJ, Huang HK, et al. Adaptive support ventilation attenuates postpneumonectomy acute lung injury in a porcine model. Interact Cardiovasc Thorac Surg. 2020;31(5):718-726. doi:10.1093/icvts/ivaa157
  24. Buiteman-Kruizinga LA, Mkadmi HE, Schultz MJ, Tangkau PL, van der Heiden PLJ. Comparison of Mechanical Power During Adaptive Support Ventilation Versus Nonautomated Pressure-Controlled Ventilation-A Pilot Study. Crit Care Explor. 2021;3(2):e0335. Published 2021 Feb 15. doi:10.1097/CCE.0000000000000335
  25. Fernández J, Miguelena D, Mulett H, Godoy J, Martinón-Torres F. Adaptive support ventilation: State of the art review. Indian J Crit Care Med. 2013;17(1):16-22. doi:10.4103/0972-5229.112149
  26. Arnal JM, Wysocki M, Nafati C, et al. Automatic selection of breathing pattern using adaptive support ventilation. Intensive Care Med. 2008;34(1):75-81. doi:10.1007/s00134-007-0847-0
  27. Zhu F, Gomersall CD, Ng SK, Underwood MJ, Lee A. A randomized controlled trial of adaptive support ventilation mode to wean patients after fast-track cardiac valvular surgery. Anesthesiology. 2015;122(4):832-840. doi:10.1097/ALN.0000000000000589
  28. Rose L, Schultz MJ, Cardwell CR, Jouvet P, McAuley DF, Blackwood B. Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children. Cochrane Database Syst Rev. 2014;2014(6):CD009235. Published 2014 Jun 10. doi:10.1002/14651858.CD009235.pub3
  29. Rose L, Schultz MJ, Cardwell CR, Jouvet P, McAuley DF, Blackwood B. Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children: a cochrane systematic review and meta-analysis. Crit Care. 2015;19(1):48. Published 2015 Feb 24. doi:10.1186/s13054-015-0755-6
  30. Wysocki M, Jouvet P, Jaber S. Closed loop mechanical ventilation. J Clin Monit Comput. 2014;28(1):49-56. doi:10.1007/s10877-013-9465-2
  31. Lellouche F, Mancebo J, Jolliet P, et al. A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med. 2006;174(8):894-900. doi:10.1164/rccm.200511-1780OC
  32. Shah SD, Anjum F. Neurally Adjusted Ventilatory Assist (NAVA). In: StatPearls. Treasure Island (FL): StatPearls Publishing; May 22, 2023.
  33. Navalesi P, Longhini F. Neurally adjusted ventilatory assist. Curr Opin Crit Care. 2015;21(1):58-64. doi:10.1097/MCC.0000000000000167
  34. Sheng Y, Shao W, Wang Y, Kang X, Hu R. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023;35(11):1229-1232. doi:10.3760/cma.j.cn121430-20230222-00101
  35. Vahedi NB, Ramazan-Yousif L, Andersen TS, Jensen HI. Implementation of Neurally Adjusted Ventilatory Assist (NAVA): Patient characteristics and staff experiences. J Healthc Qual Res. 2020;35(4):253-260. doi:10.1016/j.jhqr.2020.03.008
  36. Mandyam S, Qureshi M, Katamreddy Y, et al. Neurally Adjusted Ventilatory Assist Versus Pressure Support Ventilation: A Comprehensive Review. J Intensive Care Med. 2024;39(12):1194-1203. doi:10.1177/08850666231212807
  37. Sugunan P, Hosheh O, Garcia Cusco M, Mildner R. Neurally-Adjusted Ventilatory Assist (NAVA) versus Pneumatically Synchronized Ventilation Modes in Children Admitted to PICU. J Clin Med. 2021;10(15):3393. Published 2021 Jul 30. doi:10.3390/jcm10153393
  38. Umbrello M, Antonucci E, Muttini S. Neurally Adjusted Ventilatory Assist in Acute Respiratory Failure-A Narrative Review. J Clin Med. 2022;11(7):1863. Published 2022 Mar 28. doi:10.3390/jcm11071863
  39. Beck J, Emeriaud G, Liu Y, Sinderby C. Neurally-adjusted ventilatory assist (NAVA) in children: a systematic review. Minerva Anestesiol. 2016;82(8):874-883.
  40. Minamitani Y, Miyahara N, Saito K, Kanai M, Namba F, Ota E. Noninvasive neurally-adjusted ventilatory assist in preterm infants: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 2024;37(1):2415373. doi:10.1080/14767058.2024.2415373
  41.  Fang SJ, Su CH, Liao DL, et al. Neurally adjusted ventilatory assist for rapid weaning in preterm infants. Pediatr Int. 2023;65(1):e15360. doi:10.1111/ped.15360
  42. Rossor TE, Hunt KA, Shetty S, Greenough A. Neurally adjusted ventilatory assist compared to other forms of triggered ventilation for neonatal respiratory support. Cochrane Database Syst Rev. 2017;10(10):CD012251. Published 2017 Oct 27. doi:10.1002/14651858.CD012251.pub2
  43. Stein H, Beck J, Dunn M. Non-invasive ventilation with neurally adjusted ventilatory assist in newborns. Semin Fetal Neonatal Med. 2016;21(3):154-161. doi:10.1016/j.siny.2016.01.006
  44. Liu L, Xu X, Sun Q, et al. Neurally Adjusted Ventilatory Assist versus Pressure Support Ventilation in Difficult Weaning: A Randomized Trial. Anesthesiology. 2020;132(6):1482-1493. doi:10.1097/ALN.0000000000003207
  45. Yuan X, Lu X, Chao Y, et al. Neurally adjusted ventilatory assist as a weaning mode for adults with invasive mechanical ventilation: a systematic review and meta-analysis. Crit Care. 2021;25(1):222. Published 2021 Jun 29. doi:10.1186/s13054-021-03644-z

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What is Intraoperative Neuromonitoring?

by BioBites

Intraoperative neuromonitoring (IONM) is a technique aimed at monitoring and protecting the nervous system, particularly nerves and the spinal cord, during surgery. It is primarily used in surgeries where there is a high risk of damage to the nerves or nervous system.

Why is intraoperative neuromonitoring important?

Neuromonitor reduces the risk of permanent damage by enabling real-time monitoring of nerve functions during surgeries that may pose a threat to the nervous system. Neuromonitoring devices facilitate the surgeon’s work by identifying potential damage to nerves in procedures involving the brain, spinal cord, and nerve roots, thus providing the capability to monitor and protect nerve tissues. For instance, the use of IONM in brain tumor and spinal surgeries helps prevent complications such as sensory loss or paralysis.

Additionally, nerve monitoring can positively impact the postoperative recovery process. By minimizing permanent losses in motor and sensory functions, IONM contributes to an improved quality of life for the patient.

The Benefits of Neuromonitoring on Patient Outcomes

 Neuromonitoring offers significant health and safety benefits by enabling real-time monitoring of patients’ nervous systems during surgical procedures. Neuromonitoring devices are commonly used in brain, spinal, vascular, and thyroid surgeries, helping to minimize surgical risks by preventing damage to nerve tissues.

Surgeries Where Neuromonitoring Devices Are Commonly Used

  • Thyroid & Parathyroid Surgeries: Neuromonitoring is a crucial technology in preventing nerve injuries, particularly focusing on protecting the nerves that control the vocal cords. These nerves are located very close to the thyroid gland, and any damage to them during surgery can lead to complications such as hoarseness or even loss of voice. IONM allows the surgeon to work with precision by monitoring these nerves, thereby reducing the risk of nerve injury. The use of IONM is especially beneficial in recurrent goiter and complex thyroid surgeries, as it helps minimize issues like hoarseness and accelerates the postoperative recovery process.
  • Spinal Surgeries: In spinal surgery, IONM plays an essential role in protecting nerve roots, the spinal cord, and neural pathways. Spinal surgeries carry a high risk of nerve or spinal cord injury, necessitating a monitoring system to help the surgeon perform the procedure safely.
  • Brain Surgeries: Brain surgeries are performed in areas containing delicate neural tissues, and the use of neuromonitoring devices helps protect neurological structures by monitoring the brain and nervous system in real time.
  • Peripheral Nerve Surgeries: Peripheral nerves transmit sensory and motor signals to specific parts of the body. Damage to these nerves can lead to complications such as loss of muscle control, sensory disturbances, or pain. In peripheral nerve surgeries, neuromonitoring devices provide the surgeon with real-time information to prevent nerve damage, ensuring effective nerve monitoring.
  • Vascular Surgeries: Neuromonitoring is employed when nerves are located close to vascular structures and there is a risk of nerve injury. In surgeries on major blood vessels, protecting nerves around these structures is critical. For example, procedures like carotid artery surgery or aortic aneurysm repairs carry a high risk of nerve damage, making neuromonitoring essential for safeguarding these nerves.

FAQs

1. What are the risks of not using neuromonitoring in certain surgeries?

In surgeries where neuromonitoring is not used, the risk of nerve damage increases, which can lead to temporary or permanent neurological complications. When nerves are unprotected, patients may experience permanent paralysis, sensory loss, or other motor and sensory impairments.

2. Who performs and monitors IONM during surgery?

The neuromonitoring setup is managed by a neuromonitoring specialist, and it is used collaboratively by the surgeon and anesthesiologist throughout the surgery.

3. Is intraoperative neuromonitoring safe for all patients?

While IONM is generally considered a safe technique, the electrodes in contact with the skin can cause allergic reactions or skin irritation in some patients. Temporary side effects such as localized pain or muscle spasms may also occur in certain cases.

References:

  1. Skinner, S.A. ∙ Cohen, B.A. ∙ Morledge, D.E. Practice guidelines for the supervising professional: intraoperative neurophysiological monitoring. J Clin Monit Comput. 2014; 28:103-111
  2. R Malik, D Linos. Intraoperative neuromonitoring in thyroid surgery: a systematic review. World journal of surgery, 2016 – Springer
  3.  Wong, Andrew K., et al. “Intraoperative neuromonitoring.” Neurologic Clinics 40.2 (2022): 375-389.
  4. Shils, Jay L., and Tod B. Sloan. “Intraoperative neuromonitoring.” International anesthesiology clinics 53.1 (2015): 53-73.

Connecting a humidifier to a ventilator for optimal airway humidification.

How to Connect a Humidifier to a Ventilator?

by HumidifierUncategorized

Connecting a humidifier to a ventilator is essential to maintain optimal airway humidity and improve patient comfort. Proper integration helps prevent complications like dryness and mucosal irritation. In this guide, we’ll cover the basic steps to safely and effectively connect a humidifier to a ventilator.

Preparation Before Connecting a Humidifier to a Ventilator

Before connecting a humidifier to a ventilator, it’s crucial to follow proper procedures to ensure patient safety, system efficiency, and equipment functionality. This preparation includes taking safety precautions and ensuring that all necessary equipment and tools are available and properly functioning (3).

Safety Precautions

A. Infection Control

  • Hand Hygiene: Ensure thorough hand hygiene before and after handling any ventilator or humidifier components to reduce the risk of contamination.
  • Sterile Equipment: Use only sterile or single-use components (e.g., tubing, water reservoir) to prevent bacterial contamination.
  • Closed Circuit: Keep the circuit closed to minimize the risk of infection, especially for patients who are mechanically ventilated.
  • Use of Sterile or Distilled Water: Fill the humidifier reservoir with sterile or distilled water to prevent bacterial growth in the system.

B. Monitoring and Supervision

  • Check Patient Settings: Verify the ventilator settings before connecting the humidifier. Ensure that tidal volume, pressure settings, and oxygen levels are within the required limits.
  • Monitor Temperature: Make sure that the temperature and humidity levels are set to the recommended ranges to avoid airway burns (too hot) or inadequate humidification (too cold).

C. Avoiding Condensation (Rainout)

  • Heated Wire Circuits: If using a heated humidifier, confirm that the heated wires in the tubing are functioning correctly to prevent condensation within the circuit, which can interfere with ventilation and increase infection risk.
  • Proper Tubing Positioning: Keep the tubing slightly inclined, allowing any condensation that forms to flow back into the water chamber rather than towards the patient.

D. Equipment Inspection

  • Check for Leaks: Ensure that there are no leaks in the ventilator tubing or around the connections, as leaks can lead to a loss of pressure and improper ventilation.
  • Prevent Electrical Hazards: If using an electrical humidifier, ensure that the power supply is stable and there are no exposed wires or damaged components. Use grounded outlets to prevent electrical shocks.

E. Emergency Preparedness

  • Emergency Disconnection Plan: Be prepared to quickly disconnect the patient from the ventilator if any malfunction occurs with the humidifier (e.g., overheating or water contamination).
  • Backup Equipment: Have backup equipment, such as another humidifier or emergency respiratory support (e.g., manual resuscitator), ready in case of failure.

Necessary Equipment and Tools

A. Ventilator-Related Equipment

  1. Ventilator Unit: The mechanical ventilator should be set up and operational, with all settings configured for the patient’s needs (e.g., tidal volume, pressure, oxygen levels).
  2. Ventilator Circuit: Includes inspiratory and expiratory tubing, connectors, and a Y-piece that connects the patient to the ventilator.
  3. Filters: Bacterial/viral filters to protect the ventilator and humidifier from contamination by microorganisms.

B. Humidification Equipment

  1. Humidifier (Heated or HME):
    • For Heated Humidifiers: Ensure the water chamber, heating element, and control unit are present and functioning.
    • For HMEs: Ensure the HME is sterile, sealed, and ready to connect between the endotracheal tube or mask and the ventilator circuit.
  2. Heated Wire Circuit: If using a heated humidifier, the tubing should have built-in heating elements to prevent condensation within the ventilator tubing.
  3. Water Reservoir: A sterile water container or chamber attached to the heated humidifier. The water level should be checked and filled as necessary before starting.
  4. Water Supply: Sterile or distilled water for use in the humidifier. Avoid tap water, as it may introduce contaminants.

C. Connection Tools

  1. Connectors and Adaptors: These are needed to attach the humidifier to the ventilator circuit and patient airway. Ensure the correct size and type (e.g., Luer-lock, Y-piece connectors) are available.
  2. Tubing Clamps/Clips: These are used to secure tubing and prevent disconnection or leaks in the circuit.

D. Monitoring Tools

  1. Temperature Probe: Used to monitor the temperature at the patient end of the ventilator circuit, ensuring the air is adequately warmed and humidified.
  2. Humidity Sensor: Some advanced humidifiers or ventilators come with built-in humidity sensors to measure and adjust the humidity levels in real-time.
  3. Oxygen Analyzer: If oxygen therapy is being administered, an oxygen analyzer is used to verify the concentration of oxygen being delivered.

E. Backup and Emergency Equipment

  1. Manual Resuscitator (Ambu Bag): For immediate manual ventilation in case of ventilator or humidifier failure.
  2. Backup Humidifier or HME: In case the primary humidifier malfunctions or needs to be replaced, having a backup ensures continuous humidification.
  3. Spare Tubing and Filters: Extra tubing and filters should be readily available in case of damage or contamination during setup or use (4).

In conclusion, proper preparation before connecting a humidifier to a ventilator involves thorough inspection of equipment, adherence to infection control protocols, and careful monitoring of the system to ensure optimal patient care. Following these steps can prevent complications such as infection, condensation, and equipment malfunction.

Step-by-Step Process for Safe Connection

  1. Inspect the Ventilator and Humidifier:
    • Ensure that both the ventilator and humidifier are in good working condition, have been calibrated, and are set to the appropriate values for the patient.
  2. Set Up the Water Chamber:
    • For heated humidifiers, fill the water chamber with sterile or distilled water and check that the heating element is operational.
  3. Connect the Circuit:
    • Attach the inspiratory and expiratory tubing to the ventilator. Ensure all connectors are tight and secure to avoid air leaks.
  4. Insert the HME or Humidifier:
    • If using an HME, place it between the ventilator tubing and the patient’s endotracheal tube, tracheostomy, or mask.
    • If using a heated humidifier, connect the tubing from the ventilator to the humidifier’s output, and from the humidifier to the patient’s airway.
  5. Check Humidification Settings:
    • Set the desired temperature and humidity on the humidifier (for heated humidifiers). Ensure these are within the recommended range, typically 37°C for temperature and 30-34 mg/L for absolute humidity.
  6. Monitor and Adjust:
    • Continuously monitor the system, checking for appropriate temperature, humidity, and oxygen levels. Adjust the settings as necessary to ensure patient safety and comfort.

Humidifier Testing and Adjustments

Once the humidifier is connected to the ventilator, it is essential to perform thorough testing and make necessary adjustments to ensure proper functioning. This process includes checking for leaks, adjusting humidity levels, and continuously monitoring the patient’s comfort and safety. Each of these steps is critical to ensuring the efficiency of the ventilator-humidifier system and preventing complications (2).

1. Checking for Leaks

Leaks in the ventilator or humidifier system can reduce the effectiveness of ventilation, alter pressure settings, and result in inadequate oxygen delivery. Detecting and fixing leaks early is essential for maintaining proper ventilation support.

Steps for Checking Leaks:

  1. Visual Inspection:
    • Before starting ventilation, visually inspect all connections in the circuit (e.g., between the ventilator, humidifier, and patient) for loose fittings or disconnected tubing.
    • Ensure that all connectors, clamps, and seals are secure.
  2. Leak Test on the Ventilator:
    • Most modern ventilators have a built-in leak test function. Activate the test via the ventilator’s control panel, and it will simulate pressure within the circuit to detect any air leaks.
    • The system will notify you if there is a significant leak in the circuit.
  3. Monitor Pressure Readings:
    • During ventilation, closely monitor the airway pressure. Unexplained drops in pressure may indicate a leak.
    • If the ventilator’s pressure alarms are triggered frequently (e.g., low-pressure alarms), it could signal a disconnection or leak in the tubing or humidifier system.
  4. Tighten and Secure Connections:
    • If a leak is detected, recheck the tubing, connectors, and seals. Tighten any loose connections or replace defective components (e.g., cracked tubing or worn-out connectors).
  5. Check Water Chamber and Ventilator Seal:
    • Ensure that the water chamber in the heated humidifier is properly seated and sealed to prevent leaks around the humidifier.

Final Leak Test:

  • After addressing any potential leak points, conduct a final ventilator leak test to verify that all issues have been resolved and the system is fully sealed.

2. Adjusting Humidity Levels

Maintaining appropriate humidity levels is vital for preventing airway dryness, reducing secretion buildup, and ensuring patient comfort. Too little humidity can lead to airway irritation, while excessive humidity can cause condensation in the circuit and increase the risk of infection.

Steps for Adjusting Humidity:

  1. Initial Settings:
    • Heated Humidifier: Start by setting the humidifier to a temperature of 37°C, which typically provides adequate humidification without overheating. Humidity levels should range between 30-34 mg/L (absolute humidity).
    • HME (Passive Humidifier): HMEs do not allow for direct adjustment of humidity but rely on the patient’s own exhaled moisture and heat to humidify the inhaled air. Ensure the HME is functioning properly by checking that it is warm after a few breaths.
  2. Monitoring Humidity Output:
    • Many modern ventilators and humidifiers have sensors that display real-time humidity levels. Regularly monitor these readings to ensure the humidity is within the recommended range.
    • Place a temperature probe near the patient’s airway (typically at the end of the circuit) to ensure the gas delivered is at the correct temperature and humidity level.
  3. Adjusting for Condensation (Rainout):
    • If you notice condensation forming in the ventilator tubing (often called “rainout”), reduce the temperature slightly or use heated wire circuits to keep the air warm and prevent moisture from cooling and condensing.
    • Adjust the ambient room temperature, if necessary, to reduce condensation. A colder room may cause more moisture to collect inside the tubing.
  4. Patient-Specific Adjustments:
    • Increased Humidity Needs: If the patient has thick secretions or dry airways, you may need to increase the humidifier temperature slightly (within safe limits) to add more moisture to the air.
    • Decreased Humidity Needs: If the patient is experiencing excessive secretions or condensation, decrease the temperature or switch to an HME to reduce moisture levels.

3. Monitoring Patient Comfort and Safety

The comfort and safety of the patient are the primary concerns in mechanical ventilation. Proper monitoring ensures that the humidifier and ventilator are functioning correctly and that the patient is receiving adequate, safe care (1).

Steps for Monitoring:

  1. Observe Patient Comfort:
    • Signs of Dryness: If the patient exhibits signs of dry mouth, throat discomfort, or dried secretions, the humidity levels may be too low. Adjust the humidification settings accordingly.
    • Signs of Over-Humidification: Look for signs such as excessive secretions, coughing, or discomfort, which may indicate over-humidification. Condensation in the tubing can also suggest that humidity is too high.
  2. Monitor Respiratory Status:
    • Check the patient’s respiratory rate, tidal volume, and oxygen saturation (SpO₂) regularly to ensure that ventilation is effective and stable.
    • Watch for signs of airway obstruction, such as increased work of breathing, caused by mucus plugging due to inadequate humidity.
  3. Alarms and Ventilator Monitoring:
    • Ensure that the ventilator’s alarms are set appropriately for detecting any abnormalities in pressure, tidal volume, or oxygen levels.
    • Respond promptly to any ventilator alarms, such as low-pressure or high-pressure alarms, which may indicate issues with the humidifier, tubing, or patient airway.
  4. Temperature Monitoring:
    • Continuously monitor the temperature at the patient end of the circuit. The delivered gas should be approximately body temperature (37°C).
    • Ensure the humidifier’s heating element maintains the desired temperature and adjust if necessary to prevent overheating or under-heating.
  5. Check for Condensation in Tubing:
    • Routinely check the tubing for signs of water buildup. If condensation forms, it can obstruct airflow and affect ventilation efficiency. In case of significant water accumulation, drain the tubing and readjust the temperature to prevent further condensation.
  6. Assess Secretions:
    • Monitor the quantity and consistency of the patient’s secretions. If secretions become too thick, it may indicate insufficient humidification, requiring an increase in the humidity setting.

Patient Communication and Feedback:

  • If the patient is conscious, ask them about their comfort level. Patients on non-invasive ventilation (NIV) may report dryness or discomfort if the humidity is not sufficient. Adjust based on their feedback.

Regular Equipment Check:

  • Periodically inspect the humidifier, ventilator, and tubing to ensure all components are functioning correctly. Look for any signs of equipment failure, water contamination, or blockages in the tubing.

In conclusion, after connecting a humidifier to a ventilator, thorough testing and continuous monitoring are essential for ensuring the system’s effectiveness and the patient’s safety. Checking for leaks, adjusting humidity levels to suit the patient’s needs, and monitoring for comfort and safety ensure that the patient receives optimal respiratory support.

Adjust Humidity Levels and Troubleshooting for Humidifiers and Ventilators

Proper maintenance and timely troubleshooting are essential for ensuring the safe and effective operation of both humidifiers and ventilators in clinical settings. Regular cleaning, inspection, and awareness of common issues can help prevent complications and extend the lifespan of the equipment.

1. Regular Cleaning and Inspection

A. Importance of Cleaning

  • Regular cleaning is vital to prevent bacterial growth, mineral buildup, and contamination in humidifiers, particularly in heated humidifiers that use water reservoirs. Ventilator circuits and components also need to be cleaned and replaced to maintain patient safety and proper equipment function.

B. Cleaning Schedule

  1. Water Chamber/Reservoir (Heated Humidifier)
    • Daily Cleaning: If using a reusable water chamber, clean it daily with mild soap and warm water, and rinse thoroughly. Follow with sterilization as per manufacturer guidelines.
    • Replace as Needed: Disposable water chambers should be replaced according to the manufacturer’s instructions (often every 24 to 48 hours).
  2. Ventilator Circuit Tubing
    • Single-Use Tubing: Replace single-use ventilator circuits after each patient or as per infection control protocols.
    • Reusable Tubing: For reusable circuits, clean them daily, and sterilize them in accordance with hospital infection control standards. Ensure thorough drying before reassembling to avoid moisture buildup.
  3. Humidifier and Filters
    • Humidifier Base: Wipe the exterior of the humidifier regularly to remove dust and dirt. Ensure the heating element is clean and free of mineral buildup.
    • Filters: Replace bacterial/viral filters regularly. Follow manufacturer recommendations, typically every 24 hours, or sooner if they become visibly dirty or blocked.
  4. Heated Wire Circuits
    • Heated wires in the ventilator circuit prevent condensation. Regularly inspect the wires for proper function and ensure that they are clean and free from any buildup or damage. Replace if necessary.
  5. Humidity and Temperature Sensors
    • Inspect the temperature and humidity sensors for accuracy and cleanliness. Clean sensors carefully and recalibrate them as per the manufacturer’s guidelines.

C. Inspection Routine

  1. Daily Visual Check
    • Inspect the tubing, humidifier, and ventilator circuit for any visible signs of wear and tear, disconnections, or leaks.
    • Ensure that all connectors are secure and that there is no condensation buildup in the tubing (especially if heated humidifiers are in use).
  2. Monitor for Alarms
    • Keep an eye on any alarms or alerts from the ventilator, as these can signal issues such as leaks, blocked tubing, or inadequate humidification.
  3. Temperature and Humidity Check
    • Use a probe to regularly check the temperature and humidity levels being delivered to the patient. Compare the actual values to the set parameters to ensure the system is working correctly.

2. Common Issues and Solutions

A. Condensation or “Rainout” in the Circuit

Problem: Condensation (rainout) occurs when humidified air cools as it travels through the ventilator tubing, leading to water accumulation. This can obstruct airflow and potentially disrupt ventilation.

Solution:

  • Use Heated Wire Circuits: Heated wire circuits prevent condensation by maintaining a consistent temperature throughout the tubing.
  • Increase Room Temperature: Ensure the ambient temperature of the room is not too low, as cooler environments contribute to condensation.
  • Check Humidifier Temperature Settings: Verify that the humidifier temperature is correctly set (typically around 37°C) to prevent cooling of the air as it travels through the circuit.

B. Inadequate Humidification

Problem: If the air delivered to the patient is too dry, it can cause airway dryness, discomfort, and increased secretion thickness, leading to blockages in the airway.

Solution:

  • Adjust Humidifier Settings: Increase the humidification level on the humidifier to ensure proper moisture is delivered. Monitor the output to ensure it matches the target humidity level.
  • Switch to Active Humidification: If using an HME, and the patient’s airways are dry, consider switching to a heated humidifier for more effective and continuous humidification.
  • Monitor Water Chamber Levels: Ensure the water reservoir has adequate sterile water. Refill or replace the water chamber as needed.

C. Leaks in the Ventilator Circuit

Problem: Leaks in the ventilator circuit can reduce the pressure and volume of air delivered to the patient, compromising effective ventilation.

Solution:

  • Check All Connections: Inspect all tubing connections, ensuring they are securely attached and free from cracks or damage.
  • Perform a Leak Test: Use the ventilator’s built-in leak test feature to check for air leaks. Fix any detected leaks by tightening connectors or replacing damaged tubing.
  • Replace Worn Components: If the tubing, connectors, or seals are worn out or damaged, replace them immediately to maintain system integrity.

D. Clogged Filters or Tubing

Problem: Filters or tubing can become clogged with secretions, dirt, or condensation, increasing airway resistance and obstructing airflow to the patient.

Solution:

  • Replace Filters Regularly: Ensure that bacterial and viral filters are replaced as per the manufacturer’s instructions or when visibly soiled.
  • Clean or Replace Tubing: If tubing becomes clogged with secretions or condensation, clean or replace it immediately to prevent airway obstruction.
  • Monitor Secretions: If the patient has thick secretions, adjust the humidity level to prevent buildup in the tubing and ensure secretion mobility.

E. Overheating or Undercooling of Humidified Air

Problem: Overheating can cause burns to the airways, while undercooling may lead to inadequate humidification and discomfort for the patient.

Solution:

  • Adjust Humidifier Temperature: Ensure the humidifier is set to a safe and effective temperature (around 37°C). Monitor the output temperature regularly using temperature probes.
  • Check Temperature Sensors: Regularly inspect and recalibrate the humidifier’s temperature sensors to ensure accurate readings.
  • Avoid Direct Sunlight or Heat Sources: Keep the ventilator and humidifier away from heat sources or direct sunlight, which could interfere with temperature control.

F. Inaccurate Temperature or Humidity Readings

Problem: The ventilator or humidifier may show incorrect humidity or temperature readings due to sensor malfunctions or calibration issues.

Solution:

  • Recalibrate Sensors: Recalibrate temperature and humidity sensors according to the manufacturer’s guidelines. This will help ensure accurate monitoring.
  • Replace Faulty Sensors: If recalibration does not resolve the issue, replace faulty sensors with new, calibrated units.

G. Humidifier Not Heating Properly

Problem: The heated humidifier fails to warm the water properly, resulting in insufficient humidification.

Solution:

  • Check Power Source: Ensure the humidifier is plugged into a reliable power source and that the heating element is functioning correctly.
  • Inspect the Heating Plate: If the heating plate is dirty or has mineral deposits, clean it according to manufacturer instructions or replace it if damaged.
  • Replace the Humidifier Unit: If the humidifier continues to malfunction, it may be necessary to replace the unit to ensure proper heating and humidification.

In conclusion, maintaining a humidifier and ventilator system requires regular cleaning, inspection, and timely troubleshooting to ensure efficient and safe operation. By following a structured maintenance routine and understanding common issues and their solutions, healthcare professionals can prevent complications, extend the lifespan of equipment, and ensure optimal patient care.

Conclusion

  1. Regular Cleaning and Inspection:
    • Daily Cleaning: Clean and sterilize reusable components like water chambers and tubing, and replace disposable parts (e.g., filters and HMEs) as needed.
    • Sterile Water Use: Always use sterile or distilled water in heated humidifiers to avoid contamination.
    • Inspect Equipment: Check all connections, tubing, and humidifiers daily for signs of wear, leaks, or blockages. Perform visual inspections and run ventilator leak tests to ensure system integrity.
  2. Common Issues and Solutions:
    • Condensation (Rainout): Prevent condensation buildup by using heated wire circuits, adjusting humidifier settings, and controlling room temperature.
    • Inadequate Humidification: Monitor and adjust humidity levels to avoid airway dryness and ensure patient comfort. Switch to a heated humidifier if needed.
    • Leaks in the Circuit: Conduct leak tests and secure all connections. Replace worn or damaged tubing and connectors.
    • Clogged Filters or Tubing: Regularly replace filters and clean tubing to prevent blockages that could compromise ventilation.
    • Overheating or Undercooling: Ensure proper temperature control by regularly calibrating sensors and adjusting humidifier settings.
    • Humidifier Not Heating Properly: Check the power source and heating elements, and replace faulty components if necessary.

Tips for Optimal Performance

  1. Monitor Humidity and Temperature:
    • Continuously track temperature and humidity levels using probes and built-in sensors. Ensure that the delivered air is warmed to body temperature (around 37°C) and that humidity levels remain adequate (30-34 mg/L).
  2. Stay Vigilant About Patient Comfort:
    • Regularly assess the patient for signs of discomfort, such as airway dryness, excessive secretions, or coughing. Adjust humidification and ventilation settings as necessary to keep the patient comfortable and safe.
  3. Maintain a Backup System:
    • Always have a backup humidifier or HME, spare tubing, and filters ready in case of equipment malfunction or failure. Keep manual resuscitators (Ambu bags) nearby for emergencies.
  4. Use Heated Wire Circuits to Prevent Rainout:
    • Heated wire circuits help maintain consistent temperatures in the tubing, reducing condensation and preventing water buildup.
  5. Follow Manufacturer Guidelines:
    • Adhere to the manufacturer’s instructions for maintenance, calibration, and replacement of equipment. Regularly updating and servicing the equipment ensures its longevity and optimal performance.
  6. Respond Quickly to Alarms:
    • Set ventilator alarms appropriately and respond immediately if any alarms are triggered. This can help identify leaks, blockages, or other issues early on before they affect patient care.

By implementing these steps and troubleshooting effectively, you can ensure that the humidifier-ventilator system operates efficiently, providing safe and effective respiratory support to patients.

References

1.   Lellouche F, Taillé S, Lefrançois F, et al. Humidification performance of 48 passive airway humidifiers: comparison with manufacturer data. Chest. 2009;135(2):276–286. doi: 10.1378/chest.08-0679.

2.   Sottiaux TM. Consequences of Under- and Over-humidification. Respiratory Care Clinics of North America. 2006;12(2):233–252. doi: 10.1016/j.rcc.2006.03.010.

3.   https://rc.rcjournal.com/content/respcare/57/5/782.full.pdf

4. http://www.frankshospitalworkshop.com/equipment/documents/ventilators/service_manuals/Fisher_Paykel_Humidifiers_700-730_-_Service_manual.pdf

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Acute Respiratory Failure: Causes and Mechanisms

by ICU Ventilator

Acute respiratory failure (ARF) is a critical condition characterized by the respiratory system’s inability to maintain adequate gas exchange, presenting an immediate threat to life. Its etiologies encompass a wide range of conditions, including acute respiratory distress syndrome (ARDS), pneumonia, exacerbations of chronic obstructive pulmonary disease (COPD), and neuromuscular disorders, all necessitating timely and effective intervention.

Acute respiratory failure (ARF) is a life-threatening condition defined by the respiratory system’s inability to maintain adequate gas exchange, resulting in critically low oxygen levels in the blood (hypoxemia), elevated carbon dioxide levels (hypercapnia), or a combination of both (1). ARF can result from diverse etiologies, including acute respiratory distress syndrome (ARDS), pneumonia, chronic obstructive pulmonary disease (COPD) exacerbations, pulmonary embolism, neuromuscular disorders, or trauma (2, 3). These conditions impair the lung’s capacity to oxygenate blood and eliminate carbon dioxide, leading to severe systemic consequences if not managed promptly and effectively.

What is Acute Respiratory Failure?

Acute respiratory failure (ARF) is a medical condition in which the respiratory system fails to perform its primary function of effective gas exchange. This failure leads to inadequate oxygenation of the blood (hypoxemia), impaired elimination of carbon dioxide from the body (hypercapnia), or both (1). ARF can develop rapidly as a result of various underlying pathologies affecting the lungs, airways, chest wall, or central nervous system (2, 3).

ARF is often a life-threatening emergency that necessitates immediate medical intervention to prevent severe complications or death.

Basic Physiology of the Respiratory System

The primary role of the respiratory system is to facilitate gas exchange, ensuring oxygen delivery to tissues and carbon dioxide removal. This process depends on the proper functioning of several components (5–7):

  1. Ventilation: The physical movement of air into and out of the lungs, determined by respiratory muscle effort and airway patency.
  2. Diffusion: The exchange of gases between the alveoli and pulmonary capillaries, driven by partial pressure gradients.
  3. Perfusion: The blood flow through pulmonary capillaries, enabling gas exchange.

In ARF, a disruption in one or more of these components impairs gas exchange:

  • Hypoxemic ARF: Defined as PaO₂ < 60 mmHg with normal or low PaCO₂, resulting from impaired oxygenation.
  • Hypercapnic ARF: Defined as PaCO₂ > 45 mmHg with acidemia, caused by inadequate ventilation.

Pathophysiological Mechanisms of ARF

MechanismDefinitionCausesEffect
Ventilation-Perfusion (V/Q) MismatchMismatch between ventilated and perfused lung areas.Pulmonary embolism, pneumonia, atelectasis.Hypoxemia.
Diffusion ImpairmentReduced oxygen transfer across the alveolar-capillary membrane.ARDS, pulmonary fibrosis, interstitial pneumonia.Hypoxemia despite adequate ventilation.
HypoventilationReduced air movement in and out of the lungs, leading to CO₂ retention.CNS depression, neuromuscular disorders, obesity.Hypercapnia and secondary hypoxemia.
ShuntingBlood bypasses ventilated alveoli, preventing oxygenation.ARDS, pneumonia, large atelectasis.Severe hypoxemia unresponsive to oxygen therapy.
Increased Work of BreathingRespiratory muscles overwork to overcome resistance or poor compliance.COPD exacerbations, asthma, ARDS.Respiratory fatigue and eventual failure.
Table 1: Pathophysiological Mechanisms of ARF

Ventilation-Perfusion (V/Q) Mismatch

  • Definition: A mismatch occurs when areas of the lungs are ventilated but not perfused, or perfused but not ventilated.
  • Causes: Pulmonary embolism (low perfusion), pneumonia, or atelectasis (low ventilation).
  • Effect: Impairs oxygen delivery and carbon dioxide removal, causing hypoxemia.

Diffusion Impairment

  • Definition: Thickening or damage to the alveolar-capillary membrane reduces oxygen transfer to the blood.
  • Causes: Pulmonary fibrosis, ARDS, or severe interstitial pneumonia.
  • Effect: Decreases arterial oxygenation despite adequate ventilation.

Hypoventilation

  • Definition: Reduced air movement in and out of the lungs leads to insufficient CO₂ elimination.
  • Causes: Central nervous system depression (e.g., drug overdose), neuromuscular disorders (e.g., Guillain-Barré syndrome), or severe obesity.
  • Effect: Causes hypercapnia and secondary hypoxemia.

Shunting

  • Definition: Blood flows through areas of the lungs without gas exchange, bypassing functional alveoli.
  • Causes: ARDS, pneumonia, or large atelectasis.
  • Effect: Results in severe hypoxemia unresponsive to oxygen therapy.

Increased Work of Breathing

  • Definition: Respiratory muscles work harder to overcome airway resistance or reduced lung compliance.
  • Causes: COPD exacerbations, asthma, or ARDS.
  • Effect: Leads to respiratory muscle fatigue and eventual failure.

What are the Main Causes of Acute Respiratory Failure?

CategoryCausesExamples
Pulmonary CausesConditions directly impairing lung function.ARDS, pneumonia, COPD exacerbations, asthma, pulmonary embolism.
Extrapulmonary CausesConditions indirectly affecting the respiratory system.Neuromuscular disorders, CNS depression, thoracic cage abnormalities.
Trauma and External FactorsPhysical trauma or external agents affecting ventilation.Chest trauma, sedative overdose, toxins, or neuromuscular blockers.
Table 2: Main Causes of ARF

Acute respiratory failure (ARF) arises from a wide range of conditions affecting the respiratory system or its control mechanisms. These causes are broadly categorized as pulmonary causes, such as ARDS and pneumonia, directly impair lung function, while extrapulmonary causes, including neuromuscular disorders and CNS depression, indirectly disrupt respiratory mechanics:

Pulmonary Causes

  • Acute Respiratory Distress Syndrome (ARDS): Severe lung inflammation and alveolar damage leading to profound hypoxemia.
  • Pneumonia: Infectious consolidation of lung tissue impairs ventilation and gas exchange.
  • Chronic Obstructive Pulmonary Disease (COPD) Exacerbations: Increased airway obstruction and gas trapping result in hypercapnia.
  • Asthma: Severe bronchoconstriction impairs airflow, causing hypoxemia and hypercapnia.
  • Pulmonary Embolism (PE): Blockage of pulmonary arteries disrupts perfusion.

Extrapulmonary Causes

  • Neuromuscular Disorders: Conditions like Guillain-Barré syndrome or myasthenia gravis weaken respiratory muscles, reducing ventilation.
  • Central Nervous System Depression: Stroke, trauma, or sedative overdose impairs respiratory drive.
  • Thoracic Cage Abnormalities: Structural conditions such as kyphoscoliosis limit lung expansion.
  • Obesity Hypoventilation Syndrome: Excess weight restricts chest wall movement, leading to hypoventilation.

Trauma and External Factors

  • Chest Trauma: Rib fractures or pneumothorax compromise ventilation mechanics.
  • Toxins and Medications: Sedatives, opioids, or neuromuscular blockers depress respiratory effort or muscle function.

ARF is a multifaceted condition with diverse etiologies that disrupt normal respiratory physiology (3). Hypoxemia and hypercapnia serve as key markers of dysfunction, emphasizing the importance of understanding the underlying pathology for timely and effective management. Accurate diagnosis and targeted interventions, including mechanical ventilation, are essential to restoring respiratory function and preventing severe complications.

References

  1. Rochwerg B, Brochard L, Elliott MW, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017;50(2):1602426. Published 2017 Aug 31. doi:10.1183/13993003.02426-2016
  2. Chen L, Rackley CR. Diagnosis and Epidemiology of Acute Respiratory Failure. Crit Care Clin. 2024;40(2):221-233. doi:10.1016/j.ccc.2023.12.001
  3. Bos LDJ, Ware LB. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022;400(10358):1145-1156. doi:10.1016/S0140-6736(22)01485-4
  4. Villgran VD, Lyons C, Nasrullah A, Clarisse Abalos C, Bihler E, Alhajhusain A. Acute Respiratory Failure. Crit Care Nurs Q. 2022;45(3):233-247. doi:10.1097/CNQ.0000000000000408
  5. Haddad M, Sharma S. Physiology, Lung. In: StatPearls. Treasure Island (FL): StatPearls Publishing; July 20, 2023.
  6. Roussos C, Koutsoukou A. Respiratory failure. Eur Respir J Suppl. 2003;47:3s-14s. doi:10.1183/09031936.03.000385037.     Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006;27(4):337-349. doi:10.1055/s-2006-948288
  7. Ware LB. Pathophysiology of acute lung injury and the acute respiratory distress syndrome. Semin Respir Crit Care Med. 2006;27(4):337-349. doi:10.1055/s-2006-948288
1

An Overview of Humidification Mechanics

by with No Comment HumidifierUncategorized

Humidification plays a pivotal role in respiratory care, especially within the context of mechanical ventilation. Ensuring optimal humidity levels is essential not only for patient comfort but also for safeguarding the respiratory tract and enhancing ventilation outcomes. The mechanics behind effective humidification are designed to mimic natural airway conditions, compensating for the absence of the upper airway’s natural humidifying functions. Understanding these mechanics helps clarify why maintaining ideal humidity levels is so critical for both acute and long-term respiratory support.

Importance of Humidification in Ventilation

Humidification is critical in mechanical ventilation for several physiological reasons. First, it prevents the drying and damage of airways. When gases are delivered during mechanical ventilation, they bypass the upper respiratory tract, which naturally warms and humidifies air. Without humidification, the cold and dry gas can dry out airways, leading to discomfort, irritation, and potential damage to the mucosal lining (1,2). This prolonged exposure can cause secretions to thicken and increase the risk of airway blockage.

Second, humidification is vital for maintaining mucociliary function. The respiratory system’s mucociliary escalator relies on a well-hydrated mucus layer to trap and remove particles and pathogens. Adequate humidity keeps the mucus moist, allowing cilia to move it effectively out of the airways. In contrast, without sufficient humidity, mucus thickens, resulting in secretion retention and a heightened risk of infection (3).

Moreover, proper humidification reduces the risk of atelectasis, where mucus plugging obstructs the airways and compromises lung function. By preventing thick secretions, humidification helps maintain open airways, optimizing ventilation and oxygenation. It also aids thermoregulation by minimizing water and heat loss through the respiratory tract, thus preventing hypothermia and dehydration, especially in patients requiring prolonged ventilation.

humidifier

Enhancing Patient Comfort and Breathing Efficiency

Humidified gases enhance patient comfort by preventing dryness in the mouth, nose, and throat, which is crucial for those on long-term ventilation. Furthermore, it reduces the risk of respiratory infections by maintaining moisture in the airways, promoting pathogen clearance, and minimizing the formation of stagnant mucus, which can harbor bacteria (4).

Finally, properly humidified air decreases airway resistance, easing the effort required for breathing. This is particularly important for critically ill patients or those on ventilators, as it facilitates better gas exchange and reduces the work of breathing (5,6).

In summary, humidification is essential to maintaining respiratory function, protecting the airways, and enhancing the overall outcomes of mechanical ventilation. It significantly improves patient comfort and reduces the risks of complications associated with long-term ventilator use.

Overview of Humidifiers and Ventilators

Mechanical ventilation and humidification are essential components in respiratory care, particularly for patients requiring long-term respiratory support. Ventilators deliver oxygen to patients, and humidifiers are used to ensure that the air provided is moistened and warmed, simulating the natural humidification process of the human body (7-10).

Types of Humidifiers for Ventilators

Humidifiers used in ventilation fall into two categories: heated humidifiers, which actively heat and moisten the air delivered by the ventilator, and heat and moisture exchangers (HMEs), which capture moisture and heat from exhaled air for reuse during inhalation.

  1. Heated Humidifiers (Active Humidification)
    • These devices actively heat and add moisture to the air delivered by the ventilator, providing optimal humidification levels.
  2. Heat and Moisture Exchangers (Passive Humidification)
    • Also called “artificial noses,” these devices trap the moisture and heat from the exhaled air and reuse it during the next inhalation, offering an easier and less energy-invasive method of humidification.

Heated Humidifiers

Heated humidifiers are devices designed to add moisture and warmth to the air delivered by mechanical ventilators to patients. This is essential because mechanical ventilation bypasses the body’s natural mechanisms for humidifying and warming air, which are usually done by the nose and upper airways. Without proper humidification, dry, cold air can irritate and damage the respiratory tract.

Heated humidifier

Key Components of Heated Humidifiers:

  1. Water Reservoir/Chamber:
    • Contains water that is heated to generate moisture.
  2. Heater Element/Heated Plate:
    • Located under the water reservoir, it heats the water to produce warm, humidified air. The heating element can be adjusted to achieve the desired temperature and humidity level.
  3. Temperature Sensors:
    • Sensors monitor the temperature of the gas at the humidifier outlet and adjust the heating to ensure optimal humidification and prevent overheating.
  4. Heated Wire Circuit:
    • The ventilator circuit (tubing) often includes heated wires that help maintain the temperature of the humidified gas as it travels through the tubing to the patient, preventing condensation (rainout).
  5. Control System:
    • Modern humidifiers are equipped with control units that regulate temperature and humidity based on patient needs, ensuring precise control over the humidification process.

How Heated Humidifiers Work:

Heated humidifiers work by heating water in a chamber to create water vapor, which is then mixed with the gas flow from the ventilator. As the gas passes over the heated water, it picks up both moisture and heat. This warm, humidified gas is delivered through the ventilator circuit to the patient’s lungs, with heated wires in the tubing helping to maintain the temperature and moisture content along the way.

This ensures that the gas remains at an optimal level for the patient’s comfort and respiratory health. The temperature at the airway is typically regulated around 37°C, mimicking body temperature, to prevent cooling and condensation in the tubing. The humidifier continuously adjusts its heating to strike the right balance between temperature and moisture for effective respiratory care (11-13).

mechanical ventilator

Benefits of Heated Humidifiers:

Heated humidifiers offer several key benefits in respiratory care. They prevent the drying of airways, which can lead to irritation, excessive mucus production, and airway obstruction. By providing proper humidification, they help keep mucus thin and mobile, reducing the risk of mucus plugging that could result in atelectasis (lung collapse) or infection.

Heated humidifiers also maintain body temperature by delivering air that matches the body’s natural warmth, minimizing the risk of hypothermia, which is crucial for critically ill patients or those on long-term ventilation. Additionally, they enhance gas exchange by supporting the normal function of the lungs and respiratory system, leading to improved oxygenation and ventilation. Finally, they significantly improve patient comfort by delivering warm, moist air, preventing dryness and irritation in the airways (11-13).

Applications of Heated Humidifiers:

  • Invasive Mechanical Ventilation:
    • Heated humidifiers are commonly used in patients on invasive mechanical ventilation, such as those with endotracheal or tracheostomy tubes. These devices bypass the upper airway, eliminating the natural humidification processes of the body (12).
  • Non-Invasive Ventilation (NIV):
    • In non-invasive ventilation, such as Continuous Positive Airway Pressure (CPAP) or Bi-level Positive Airway Pressure (BiPAP), heated humidifiers are often used to enhance comfort and maintain airway moisture (12).

Challenges and Considerations:

  1. Condensation (Rainout):
    • One of the common challenges is condensation within the ventilator tubing, which can occur when the humidified air cools down as it travels through the circuit. This “rainout” can lead to water accumulation in the tubing, which may disrupt ventilation and increase the risk of infection. Heated wires in the circuit help mitigate this issue by maintaining a constant temperature.
  2. Infection Risk:
    • Heated humidifiers require regular cleaning and maintenance to prevent bacterial growth in the water reservoir. The use of sterile or distilled water is crucial to minimize the risk of contamination.
  3. Energy Consumption:
    • Heated humidifiers require electrical power to maintain the heating element, making them more energy-dependent than other forms of humidification like heat and moisture exchangers (HMEs).
  4. Monitoring and Adjustment:
    • Regular monitoring is needed to ensure that the humidity and temperature are set at appropriate levels, tailored to the patient’s needs (17-21).

Comparison with Other Humidification Methods:

  • Heat and Moisture Exchangers (HME):
    • Unlike heated humidifiers, HMEs are passive devices that trap moisture and heat from the patient’s exhaled air and return it during inhalation. While they are simpler and do not require power, HMEs are less effective in long-term ventilation or for patients with high minute ventilation.

In conclusion, heated humidifiers are essential for ensuring optimal humidification and temperature control in mechanically ventilated patients, especially in critical care settings. Their ability to provide warm, moist air helps prevent complications associated with dry airways, improves patient outcomes, and enhances overall comfort.

Heat and Moisture Exchangers (HMEs)

Heat and Moisture Exchangers (HMEs), also known as “artificial noses,” are passive devices used in respiratory care to conserve moisture and heat in the breathing circuit of mechanically ventilated patients. Unlike active humidifiers, which add heat and water vapor to the air, HMEs capture and reuse the patient’s own exhaled heat and moisture to humidify the inhaled air.

HMEs

Key Components of HMEs:

  1. Core (Moisture Retaining Material):
    • The core of the HME is made of hygroscopic material (e.g., paper or foam) coated with salt or other substances that retain moisture and heat.
  2. Filter:
    • Some HMEs include a bacterial or viral filter to trap pathogens, offering additional protection against infections.
  3. Housing:
    • The outer shell is typically plastic and designed to fit into the ventilator circuit. It connects between the endotracheal tube or tracheostomy tube and the ventilator tubing.

How HMEs Work:

During Exhalation the warm, moist air passes through the HME. The hygroscopic material in the HME absorbs moisture and retains the heat from the exhaled air.

During Inhalation the air passes back through the HME. The retained moisture and heat from the exhaled air are transferred to the cool, dry inhaled air, warming and humidifying it before it reaches the lungs.

This cycle repeats with every breath, continuously maintaining humidity and temperature within the respiratory system (23).

Heat and Moisture Exchangers

Types of Heat and Moisture Exchangers (HMEs):

  1. Simple HME:
    • These HMEs passively trap heat and moisture from exhaled air without any active warming or humidification. They are inexpensive and widely used in short-term ventilation.
  2. Hygroscopic HME:
    • These HMEs use special materials, such as calcium chloride, which enhance moisture retention from exhaled air. They offer better humidification compared to simple HMEs.
  3. Hydrophobic HME:
    • Made from water-repellent materials, these HMEs focus on capturing heat rather than moisture. They also help reduce bacterial contamination by acting as a filter.
  4. HME with Integrated Filters:
    • These devices incorporate bacterial/viral filters to trap pathogens, offering a dual function of humidification and infection prevention.

Benefits of Heat and Moisture Exchangers:

Heat and Moisture Exchangers (HMEs) offer several benefits, particularly in terms of simplicity and convenience. They are easy to use, disposable, and require no power source or complex setup, making them ideal for short-term or emergency ventilation situations. HMEs are also cost-effective compared to heated humidifiers, with less need for maintenance, which makes them suitable for temporary or non-invasive ventilation.

Additionally, because they are single-use devices, HMEs reduce the risk of cross-contamination and eliminate the need for continuous cleaning and sterilization, unlike heated humidifiers that require regular disinfection. Their lightweight and portable design also makes them highly practical for non-invasive ventilation (NIV) and patient transport scenarios (24).

Limitations of HMEs:

Heat and Moisture Exchangers (HMEs) have several limitations, particularly in high-demand respiratory situations. Their efficiency decreases in patients with high minute ventilation, where large volumes of air need to be humidified. This can lead to airway dryness, mucus plugging, and lung complications. Additionally, excess moisture can cause the HME to become saturated, resulting in increased resistance, potential blockage, and reduced effectiveness in delivering humidified air.

HMEs are generally intended for short-term use, typically up to 48 hours, making them less suitable for long-term ventilation where heated humidifiers are more effective. They also add a small amount of dead space to the ventilator circuit, which can increase the work of breathing, especially in pediatric or neonatal patients.

Furthermore, HMEs are less effective in certain clinical situations, such as with patients who have thick or copious secretions, and are not recommended for those requiring high levels of humidity or oxygen, such as patients on high-flow oxygen therapy (23-25).

Applications of HMEs:

  1. Invasive Mechanical Ventilation:
    • HMEs are commonly used in patients on invasive ventilation, particularly those who require short-term ventilation in settings like the operating room, recovery rooms, or emergency departments.
  2. Non-Invasive Ventilation (NIV):
    • HMEs are also used with NIV devices such as Continuous Positive Airway Pressure (CPAP) or Bi-level Positive Airway Pressure (BiPAP) systems. They help improve comfort and maintain airway moisture in patients using masks for ventilation.
  3. Post-Surgical Care:
    • In post-operative settings, HMEs are useful in maintaining airway moisture for patients recovering from surgeries, especially in cases where mechanical ventilation is required for short periods.
  4. Home Care and Transport:
    • HMEs are favored in home care settings for patients on ventilators due to their simplicity and low maintenance. They are also commonly used during patient transport, where active humidifiers may not be feasible.

Comparison Between HMEs and Heated Humidifiers:

AspectHeat and Moisture Exchanger (HME)Heated Humidifier
MechanismPassively conserves moisture and heatActively adds moisture and heat
Power RequirementNo power requiredRequires electrical power
Humidity ControlLess precise; relies on patient exhalationPrecise control over humidity and temperature
EfficiencyLess effective in high minute ventilationHighly effective for long-term ventilation
CostLow, disposableHigher cost, requires regular maintenance
Infection ControlSingle-use, minimizes contaminationNeeds regular cleaning to prevent infection
ApplicationsShort-term, low-risk ventilationLong-term ventilation, critically ill patients

In conclusion, Heat and Moisture Exchangers (HMEs) are valuable tools in respiratory care, providing a simple, low-cost method for humidifying and heating the air in mechanically ventilated patients. While they are highly effective for short-term or low-ventilation needs, they have limitations in long-term or high-minute ventilation scenarios. For patients requiring prolonged ventilation, heated humidifiers may offer better humidification and temperature control.

References

  1. van Oostdam JC, Walker DC, Knudson K, Dirks P, Dahlby RW, Hogg JC. Effect of breathing dry air on structure and function of airways. Journal of Applied Physiology. 1986;61(1):312–317. doi: 10.1152/jappl.1986.61.1.312.
  2. Fonkalsrud EW, Sanchez M, Higashijima I, Arima E. A comparative study of the effects of dry vs. humidified ventilation on canine lungs. Surgery. 1975;78(3):373–380.
  3. Mercke U. The influence of varying air humidity on mucociliary activity. Acta Oto-Laryngologica. 1975;79(1-2):133–139. doi: 10.3109/00016487509124665.
  4. Ballard ST, Inglis SK. Liquid secretion properties of airway submucosal glands. Journal of Physiology. 2004;556(1):1–10. doi: 10.1113/jphysiol.2003.052779.
  5. Bryant LR. A technique for adequate humidification with mechanical respirators. The Journal of Thoracic and Cardiovascular Surgery. 1963;46:404–407.
  6. Chatburn RL, Primiano FP., Jr. A rational basis for humidity therapy. Respiratory Care. 1987;32(4):249–254.
  7. American Association for Respiratory Care, Restrepo RD, Walsh BK. Humidification during invasive and noninvasive mechanical ventilation: 2012. Respiratory Care. 2012;57(5):782–788. doi: 10.4187/respcare.01766.
  8. Cairo JM. Mosby’s Respiratory Care Equipment. 9th edition. St. Louis, Mo, USA: Mosby, Elsevier; 2013.
  9. Branson RD. Humidification for patients with artificial airways. Respiratory Care. 1999;44(6):630–641.
  10. Kacmarek RM, Stoller JK, Heuer AH. Egan’s Fundamentals of Rrespiratory Care. 10th edition.
  11. Carter BG, Whittington N, Hochmann M, Osborne A. The effect of inlet gas temperatures on heated humidifier performance. Journal of Aerosol Medicine. 2002;15(1):7–13. doi: 10.1089/08942680252908539.
  12. Nishida T, Nishimura M, Fujino Y, Mashimo T. Performance of heated humidifiers with a heated wire according to ventilatory settings. Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung. 2001;14(1):43–51. doi: 10.1089/08942680152007882.
  13. Solomita M, Daroowalla F, LeBlanc DS, Smaldone GC. Y-piece temperature and humidification during mechanical ventilation. Respiratory Care. 2009;54(4):480–486.
  14. Solomita M, Palmer LB, Daroowalla F, et al. Humidification and secretion volume in mechanically ventilated patients. Respiratory Care. 2009;54(10):1329–1335.
  15. Boots RJ, George N, Faoagali JL, Druery J, Dean K, Heller RF. Double-heater-wire circuits and heat-and-moisture exchangers and the risk of ventilator-associated pneumonia. Critical Care Medicine. 2006;34(3):687–693. doi: 10.1097/01.CCM.0000201887.51076.31.
  16. Lellouche F, Lyazidi A, Rodriguez P, Brochard L. Condensation in inspiratory and expiratory circuits of heated wire humidifiers, evaluation of a new expiratory, “porous”, circuit and of new humidification compensation systems. Proceedings of the 100th International Conference of the American Thoracic Society; 2005; San Diego, Calif, USA. 
  17. Gilmour IJ, Boyle MJ, Streifel A, McComb RC. The effects of circuit and humidifier type on contamination potential during mechanical ventilation: a laboratory study. The American Journal of Infection Control. 1995;23(2):65–72. doi: 10.1016/0196-6553(95)90096-9.
  18.  http://www.cdc.gov/hicpac/pdf/guidelines/HApneu2003guidelines.pdf.
  19. Wong DHW. Melted delivery hose—a complication of a heated humidifier. Canadian Journal of Anaesthesia. 1988;35(2):183–186. doi: 10.1007/BF03010661.
  20. Schumann S, Stahl CA, Möller K, Priebe H-J, Guttmann J. Moisturizing and mechanical characteristics of a new counter-flow type heated humidifier. British Journal of Anaesthesia. 2007;98(4):531–538. doi: 10.1093/bja/aem006.
  21. Jones SW, Short KA, Joseph M, Sommer C, Cairns BA. Use of a new novel humidification system with high frequency percussive ventilation in a patient with inhalation injury. Journal of Burn Care and Research. 2010;31(3):499–502. doi: 10.1097/BCR.0b013e3181db51e5.
  22. Hingorani BK. The resistance to airflow of tracheostomy tubes, connections, and heat and moisture exchangers. British Journal of Anaesthesia. 1965;37(6):454–463. doi: 10.1093/bja/37.6.454.
  23. Vandenbroucke-Grauls CM, Teeuw KB, Ballemans K, Lavooij C, Cornelisse PB, Verhoef J. Bacterial and viral removal efficiency, heat and moisture exchange properties of four filtration devices. Journal of Hospital Infection. 1995;29(1):45–56. doi: 10.1016/0195-6701(95)90292-9. 
  24. Lellouche F, Taillé S, Lefrançois F, et al. Humidification performance of 48 passive airway humidifiers: comparison with manufacturer data. Chest. 2009;135(2):276–286. doi: 10.1378/chest.08-0679.
  25. Martin C, Perrin G, Gevaudan MJ, Saux P, Gouin F. Heat and moisture exchangers and vaporizing humidifiers in the intensive care unit. Chest. 1990;97(1):144–149. doi: 10.1378/chest.97.1.144.
distributorship-of-medical-devices

Distributorship of Medical Devices: Tips and Strategies for Success

by with No Comment Uncategorized

In the healthcare world, it is essential that the distribution of medical devices is effective enough to let advanced technologies reach every healthcare provider. With the growing demand for the medical solutions, it has become essential to understand the distributorship of medical devices and follow a proactive approach and implement strategic insights. Whether it’s building strong partnerships with manufacturers or understanding the market dynamics, you can get success through customer-centric strategies, operational efficiency and market knowledge.

So, let’s explore the tips and valuable strategies to empower medical distributors in this competitive world of medical device distribution.

distributorship of medical devices slider

The Importance of Medical Device Distribution

A well-planned medical device distribution ensures that all innovative healthcare solutions reach the healthcare centers to benefit patients. The medical distributors ensure that this supply chain from medical device manufacturers and end-users remains smooth.

Roles of Distributors in the Healthcare Sector:

Medical distributors bridge the gap between manufacturers and the end-users through different roles and responsibilities. The different roles are:

  • With their market knowledge and extensive network, medical device distributors broaden the customer reach of manufacturers, enabling them to access customers from clinics, hospitals, healthcare facilities and laboratories.
  • As distributors have in-depth knowledge of products they distribute, they can provide important information, training and technical support to healthcare professionals. This ensures that devices are used safely in the right manner.
  • Medical distributors ensure that the medical devices meet all regulatory compliances and certifications of the healthcare industry.
  • With strong relationship building skills, medical distributors maintain healthy relations with customers, build manufacturer’s reputation over time and facilitate long-term business with healthcare professionals.
  • It’s the distributors who understand the healthcare policies, market dynamics and reimbursement systems. With this knowledge, they facilitate greater market access to affordable and advanced medical devices for the end-users.
  • By coordinating with the warehouse, transportation and inventory management staff, medical distributors ensure effective logistics management. They optimize the supply chain so that medical devices reach the needy in a timely and cost-effective manner.
  • They also control inventory and perform demand forecasting to avoid understock conditions.
distributorship of medical devices

Distribution Agreements and Legal Requirements

To ensure a healthy and legal distributorship in medical devices, a distribution contract or agreement occurs between device manufacturers and distributors. These agreements/contracts define the roles, responsibilities and duties of both the parties.

Key elements of Distribution Contracts:

The distribution contract contains:

  • Geographical territory in which disturbers can sell medical devices.
  • Scope of the distribution including models, product lines and variations.
  • Rights and duties of the distributors regarding the marketing and promotion of medical devices in the defined territory.
  • Pricing structures, payment terms and discounts agreed by both the [parties
  • Duration of the distribution contract and conditions of termination.
  • Intellectual property rights of the medical products such as those related to patents, trademarks and proprietary information.
  • Regulatory compliances and legal requirements of the medical devices.
  • Clauses and mechanisms to resolve any disputes if occur between distributor and manufacturer.

Medical distributorship must follow a certain framework of national/international regulations. The national regulations may include obtaining license for distributing medical devices, adhering to strict quality management systems, complying with national safety standards and reporting any negative incidents, following rules regarding labeling & packaging and advertising & promotion of medical devices.

The international regulations mainly facilitate harmony across different countries regarding medical device distribution. Also, it is essential for distributors to stick to the ISO standards specific to the medical equipment. Additionally, for EU market distribution, distributors must follow some EU regulations including MDR, IVDR, etc. Similarly, for the marketing and distribution of medical devices in the US, distributors must comply with FDA regulations. Besides, there are several other international standards and regulations that provide recommendations for the safe distribution of medical devices.

Strategies to Become a Successful Distributor:

If you want to become a successful medical device distributor, you need to follow a strategic approach encompassing industry knowledge, regulatory compliance, operational efficiency and healthy relationships with manufacturers.

Some key strategies you can consider are:

  • A thorough market research to understand the requirements, priorities and challenges of the healthcare providers.
  • Establish long, healthy and strong partnerships with reputable manufacturers.
  • Establish a strong distribution network with key organizations in the healthcare industry including clinics, hospitals, purchasing groups and regulatory bodies. Collaborate with them closely to understand and influence policies, and access new business opportunities.
  • Optimize and create a strong logistics and supply chain to ensure efficient and timely delivery of the medical devices.
  • Develop strong marketing and promotional strategies to increase demand and raise awareness for medical devices. Showcase specific benefits of your products through digital marketing channels and industry conferences.
  • Another important aspect for distributors is to stay agile and proactive. Regularly study competitors’ activities, market trends, and customer feedback. Accordingly, identify new opportunities and plan innovative solutions to address the evolving needs. Also, stay updated with technological advancements, regulatory changes and industry trends through education and training.

Logistics and Inventory Management

An important role of the medical distributors in ensuring timely access to the medical devices is logistics and inventory management. It is the duty of the distributor to maintain product integrity and its compliance with standards till it reaches the end user.

For this, logistics need to be effectively managed by coordinating different components of the supply chain. These include transportation, storage and distribution facilities. Distributors need to optimize the supply chain in a way to minimize lead times, prevent stockouts and manage essential inventory levels.

Additionally, they need to track product availability, lot numbers, expiration dates so that devices are stored with utmost safety and efficacy. With robust logistics and supply chain management, medical distributors ensure operational efficiency and meet customer demands on time, upholding the regulatory compliances and highest standards of product quality.

medical devices distributorship

Challenges Faced in Medical Device Distribution

Medical device distribution is not all an easy field and distributors need to navigate through several challenges to ensure efficient and regulatory compliant supply chain operations. Some challenges include:

  • Need to meet several evolving regulatory compliances across different regions and countries. The process is complex and time-consuming.
  • Requires effective management of logistics to ensure timely delivery of products at minimal costs.
  • Maintain product quality throughout the distribution process by following strict quality management systems.
  • Plan effective strategies to access new markets and stay ahead of the competitors and build strong relationships with healthcare providers.
  • Plan efficient pricing strategies to balance compliance and quality with cost-effectiveness. It includes managing operational costs, negotiating favorable terms and optimizing inventory management practices. All this needs to be planned in a manner to deliver value to the customers and maintain profits for the distributor.

The Future of Medical Device Distribution

Undoubtedly, the medical devices distribution is going to transform in future, all thanks to digitization, e-commerce and evolving technologies. All these new technologies will redefine the field of medical device distribution. With digitization, the distribution channels can streamline the process and enhance transparency, ultimately enhancing the efficiency of the distribution.

Also, the e-commerce platforms will play a major role in connecting distributors and healthcare providers for easy and convenient access to medical devices. further, emerging trends like blockchain technology and AI will optimize logistics, ensure product authenticity and predict demand patterns.

Lastly, the personalized medicine and rise in telehealth features have increased demand for remote monitoring solutions. This, in turn, will restructure the distribution for catering individual needs.         

All in all, the distribution network will evolve to ensure faster medical device access, higher patient benefits and greater efficiency in the delivery of healthcare products.

Conclusion

In conclusion, effective medical device distribution is essential to meet the rising needs of patients and healthcare providers alike. We, at Biosys Biomedical, ensure that the best and high-quality medical devices reach patients worldwide.  We develop and distribute a wide range of healthcare devices to meet evolving needs. Contact us for more information.  

References

Medical Device Distributors: Their Role in Healthcare (hub.healthcare)

The Future of Healthcare: How Distributors Play a Vital Role – Cool Bio

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Medical Devices Worthy of Investment: Future Healthcare Technologies

by with No Comment Uncategorized

You will agree that investing in long-haul businesses such as medical devices is one of the best for any capitalist in the present stock market. Its sustainability, heavy product demand, and future trends are some of the unique features that make it a worthwhile business to invest in. As a matter of fact, these medical device investments not only yield significant profits but also contribute to societal growth and overall well-being.  

Additionally, these clinical devices have also been proven to be a good option for long-term benefits due to the various technological advancements. It even provides a lot of economic and medical benefits such as improved patient outcomes, accurate diagnostic treatment, etc. 

So, are you looking for the perfect healthcare devices to invest in? You have come to the right blog. Stay tuned! 

medical device investment

1. AI-powered Diagnosis and Imaging System

Ever since the introduction of artificial intelligence following the COVID-19 pandemic, medical diagnosis and pathogenic detection have witnessed a great turnaround. It has even made the visualization of human body structures more understandable by improving its quality, accuracy, and efficiency. In fact, these AI-powered devices have made medical imaging simple with the help of some unique features like VR, AT, 3D reading, and so on. 

Consequently, some of these radiological devices such as radiomics, CT fluoroscopy, MRI hybrid imaging, etc are said to be valuable medtech systems due to their distinct features. So, as an investor, you can opt for a diagnostic medical device investment because it holds more potential for the future. 

2. Robotic Surgical Systems

The use of robotic devices to perform minimally invasive surgeries is becoming common these days. Most surgeons are already putting this act into use as it redupContinueces blood loss, and surgical pain and provides quick recovery. This advanced surgical system is a technique that many hospitals are planning to put into practice in the coming years.

Therefore, investing in this type of system can be very valuable as it provides a greater edge to laparoscopic surgery. It’s a medical device investment that will pay off because of its precise procedure and minimal postoperative problems for complex surgeries like mitral valve repair, pancreatectomy, etc.

3. Telemedicine and Remote Healthcare Service

The Covid 19 pandemic has brought a lot of changes to many activities most especially in the case of providing services remotely. One of these exceptional services in the healthcare field is the telemedicine program. This tech treatment and diagnostic also called telehealth has grown beyond expectation as it aids patient care and treatment irrespective of their distance.

medical device investment slide 2

4. Advance Patient Monitoring System

Another valuable medical device investment that is liable to yield more interest is the advanced monitoring system. They are IoT-integrated devices that aid in proper health monitoring of a patient’s medical condition. In most cases, it often involves a focus from a healthcare provider on the end-user. 

On most occasions, this monitoring system uses some specialized applications to keep a tab on patients in the ICU and also during operation. You can even invest in this device software as it is going beyond its use in the hospital only but also serves as an avenue for the home care channel.

5. Portable Diagnostic Device

When we are talking about medical devices that are already undergoing a great increase in demand across the globe, portable diagnostic devices are one of them. As we all know nowadays different things can cause a change in our health status, so taking our vital signs regularly is definitely important. These devices have been fashioned into mobile apparatus such as wristwatches, smartphones, tablet computers, etc that can be used at any point in time.

Venturing into portable diagnostic medical device investment is very lucrative and profitable as everyone seeks to have quick and easy access to their health. Statistics show that there is a high demand for products in the market.

6. Biotechnological Devices and Laboratory Equipment

Apart from investing in most of these medtech systems, another medical device investment that is also everlasting is funding research and biotech labs. A lot of researchers are trying to know more about the world and also proffer cures for many diseases. In the quest for this, the use of fast and accurate devices such as confocal microscopes, autoclaves, and electron microscopes is highly needed. Therefore, investing in these machines can bring a lot into your purse now and forever. 

Furthermore, the advent of cloning and genomic diagnosis have risen beyond imagination and a slew of molecular automation devices are gradually emerging. Thus, funding this type of project can be a future gain for investors.

Factors to Consider When Investing

When you want to invest in medical devices, there are a series of factors that you need to put into consideration before placing your money on them. Some of the most crucial components are highlighted below: 

  • Device investment and purchase regulation
  • Medical Company Certification (PAHO approved)
  • Statistical trend and purpose of medical devices
  • Current competitive analysis of the system
  • Risk Management of the medical device investment 
  • Long-term strategy and future potential.
  • Tax implications and expected returns

In Conclusion

When we are talking about businesses worthy of investment, medical devices such as the above listed are a couple of products you can fund. They are special healthcare technologies that hold a lot of promise and profits for the future. Because they provide several benefits apart from making more money and saving lives, they are like assets to the owner. But, it’s advisable to weigh their various pros and cons, particularly the company’s reputation

So, if you are a type that is looking for a reliable medical device investment company? You can reach out to Biosys Biomedical today!

References

https://typeset.io/questions/what-is-the-importance-of-investing-on-health-and-medical-5d26kdfoo1

https://enlitic.com/blogs/new-innovations-in-radiology/#:~:text=

https://my.clevelandclinic.org/health/treatments/22178-robotic-surgery

https://www.medicalnewstoday.com/articles/telemedicine

https://www.sciencedirect.com/science/article/pii/S2949866X24000030#:~:text=

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/mobile-health-application

https://www.gminsights.com/industry-analysis/portable-medical-devices-market#:~:text=

the importance of biomedical-engineers in medical device sector cover photo

The Importance of Biomedical Engineers in Medical Device Sector

by with No Comment HFO

The medical device sector is the point where healthcare meets technology and here, you cannot ignore the importance of biomedical engineering. This field ensures rapid advancements in the development of several life-saving medical devices, be it diagnostic tools or therapeutic instruments. Only when the cutting-edge engineering technology combines with the knowledge of the medical sector, do you get solutions for complex healthcare problems. As a result, there is rising demand for biomedical engineers.

This article will discuss everything about the role, contributions and importance of biomedical engineers in the medical device sector.

importance of biomedical engineers

Definition and Scope of Biomedical engineering

In the field of biomedical engineering, biomedical engineers apply design concepts and engineering principles to biology and medicine to develop healthcare solutions. The activities may range from developing medical and diagnostic equipment, creating biocompatible materials and therapeutic strategies.

Medical devices and biomedical engineering

Biomedical engineers use their expertise to improve and innovate medical devices required for diagnosis, treatment and care of the patients; right from the concept to getting regulatory approval. These devices may include imaging systems like ultrasound and MRI, robotic surgical tools and other therapeutic devices and implantable devices like pacemaker and other artificial organs. The biomedical engineers mainly aim to develop devices which are effective, safe, reliable and comply with the stringent healthcare standards.

Biomedical engineering plays an important role in enhancing diagnostic accuracy and improving treatment results for the betterment of the patients’ life.

Roles and responsibilities of biomedical engineers:

Biomedical engineers have a pivotal role in bringing together healthcare and engineering innovation. The main role and responsibilities include:

  • Designing and development of medical devices to meet specific medical needs by doing research, conceptualizing product designs, and using computational tools to optimize device performance.
  • Testing prototypes to ensure they comply with all safety and efficiency standards and pass through all rigorous testing processes.
  • Close collaboration with healthcare providers to comprehend medical requirements and use feedback in device improvement.
  • Implementing and integrating new technologies in the clinical practice
  • Providing training to medical personnel for the use and maintenance of the devices

Contributions to Medical Device Development

All thanks to the expertise and knowledge of biomedical engineers, it is possible to drive innovation and technical advancements in the medical device sector. By combining their engineering knowledge with biology understanding, they can create practical solutions.

The Role of Biomedical Engineers in Design and Development Processes

In the initial stages of developing medical devices, they collaborate with healthcare professionals to identify their needs. Based on that they conceptualize and design a new medical device. For this, they integrate advanced materials, use innovative electronics and software to get a fully-functional, reliable and user-friendly product prototype.

This prototype design is based on the intensive research of engineers in interdisciplinary fields like bioinformatics, biomechanics and biomaterials. With this research, they explore new materials, technologies and methodologies for developing medical devices which are functional, safe and durable.

Once the prototype is ready, biomedical engineers validate the design through experimentation, modeling and simulation and optimize it to meet all sorts of clinical and regulatory requirements.

Not only the design and development of medical devices, biomedical engineers also strive to integrate modern technologies like robotics, AI and nanotechnology on their products. These technologies enable medical devices to perform tasks more precisely, automatically and also provide real time data on improved treatment outcomes.

biomedical engineering

Role of Biomedical Engineers in Maintenance and Repair of Medical Devices

Apart from the design and development of devices, biomedical engineers also play a major role in the maintenance and repair of these devices. This ensures that they remain functional, reliable and safe in their healthcare operations.

Their main role in repairing and maintenance include:

  • Preventive maintenance to ensure ongoing longevity and reliability of devices. For this, they schedule regular maintenance based on the industry standards and manufacturer’s guidelines. In this, they often check performance, replace components if required and conduct inspections.
  • For any malfunctions and emergency issues, biomedical engineers perform troubleshooting and diagnostics with the help of different software, diagnostic tools and their technical expertise. They find the root cause of the issue and apply corrective measures.
  • Perform servicing and repairs to restore the functional aspects of the devices. Engineers have technical expertise to disassemble the whole devices, repair and replace the faulty components and recalibrate the medical devices to perform their specific functions. While repairing, engineers follow stringent protocols and quality assurance measures.
  • Based on the user feedback, biomedical engineers continuously work to improve the device performance metrics. They also propose any enhancements, upgrades and modifications in the design to match the product with the evolving medical needs.

Education and Competencies of Biomedical Engineers

In this fast-evolving field of healthcare solutions, the importance of biomedical engineers cannot be denied. However, to be a biomedical engineer, one should have the right education, skills and competencies. Most biomedical engineers hold a bachelor’s degree in biomedical or any related engineering field such as mechanical, chemical, and electrical. For advanced degrees, one can go for Masters or Ph.D. in biomedical engineering or any specialized engineering or medical field.

Additionally, a biomedical engineer needs to have some core competencies. For instance, they should have a strong foundation of all biomedical and engineering subjects. Skill for medical device development is also an essential part of their education. Further, they must also be proficient in biomedical instrumentation and should be well-versed with regulatory requirements of the medical field.

This diverse skill set and comprehensive education help biomedical engineers contribute towards the advancement and innovation of healthcare technology. Further, it is also essential for them to continuously upgrade their education and implement the new and evolving technologies in the field.

Future Role and Importance of Biomedical Engineering

The Future Role and Importance of Biomedical Engineering

As advancements in technology and new requirements occur, the role and importance of biomedical engineering will continue to expand. To this end, biomedical engineers will continue to develop medical technologies like implantable devices, wearable health monitors, and personalized clinical solutions.

Further, we may also witness the integration of AI, big data analytics and machine learning in devices for more predictive analysis and precise diagnosis.

Apart from this, there will be innovation in imaging technologies like CT scans and MRI, resulting in improvement in their speed, accessibility and resolution. There will be greater inclination towards therapeutic procedures like robotic surgeries, minimally invasive surgeries and targeted drug delivery equipment.

To make the medical devices more affordable and approachable, biomedical engineers will continue to work on developing affordable and portable devices for remote populations.

All this will go hand in hand with ethical consideration and regulatory compliances to ensure safety, equity and privacy in healthcare device distribution.

In Conclusion

And similar efforts have been undertaken by Biosys Biomedical, a company actively involved in the manufacturing of highly innovative and advanced medical devices. We design, develop, and manufacture state-of-the-art devices to meet the evolving clinical needs of the healthcare industry. Contact us for more information.

References

  1. A biomedical engineer’s role in a healthcare facility (healthcarefacilitiestoday.com)
  2. 9 Role of biomedical engineers in the management of medical devices from HUMAN RESOURCES FOR MEDICAL DEVICES: The role of biomedical engineers on JSTOR
  3. What does a biomedical engineer do? – CareerExplorer

history-of-global-pandemics-and-epidemics-cover

History of Global Pandemics and Epidemics

by with No Comment HFO
history of global pandemics and epidemics

Introduction: The Impact of Pandemics on Humanity Throughout History

A little over four years ago, the world was reminded once again of the frailty of life, illness, death, global disease, and global disruption by the COVID-19 pandemic. Words like quarantine, lockdown, pandemic, social distancing, hand-washing, sanitizers, and isolation, among others became a part of our day-to-day language. The impact of the most recent pandemic was far-reaching worldwide. The social, emotional, economic, and political disruption felt in the wake of the COVID-19 pandemic is starkly reminiscent of the generalized impact associated with pandemics and epidemics from time immemorial.

Pandemics and epidemics have always been a part of human history, and they remain so as the COVID-19 pandemic proved just recently. Pandemics and epidemics of flu, cholera, malaria, and HIV/AIDS are still a part of daily living across the world. From medieval times to the present time, humans have lived with disease causing organisms, and human disruption of the social and biological strata often leads to infection with some disease causing organisms, with increased industrialization and globalization leading to the eventual spread beyond the initial area of contact. 

Pandemics and Epidemics are used to show the extent of the spread of infectious and non-infectious disease conditions, with the difference being the extent and area of spread. To help understand the difference between epidemic and pandemic, it is crucial to also understand some key public health terms such as outbreak and endemic. An outbreak refers to an unexpected increase in the number of people with a particular health condition or the spread of a health condition in a new area. Endemic means that the health condition occurs at an anticipated rate in a geographical area. An epidemic is an outbreak that spreads to a larger geographical area; meaning an unexpected increase in health conditions or new cases of a health condition across larger geographical areas. Pandemic is an epidemic that spreads across continents globally.1,2

From Ancient Times To The Middle Ages: Historical Pandemics

Pandemics have been around since ancient times. Some of the pandemics recorded in history from ancient times to the Middle Ages include:

  • Athenian Plague: This occurred between 430-26 BC during the Peloponnesian war between Athens and Sparta.3 Originating from Ethiopia and spreading throughout Egypt and Greece, the initial symptoms were headaches, conjunctivitis, body rash, and fever followed by later symptoms of hemoptysis (coughing out blood), stomach pain, vomiting, and eventual death in most people.3,1 The war led to the rapid spread of the disease and was marked by the mortality of about 25% of the city’s population, despair, and breakdown of law and order.3, 1
  • Antonine Plague: Also known as the ague of Galen, it occurred between 165 – 180 AD in the Roman Empire.1 It was transmitted into the Empire by soldiers returning from war, spreading to a larger geographical area including Asia Minor, Greece, Egypt, and Italy.4 About 33% of the population or 5 million people including Marcus Aurelius, the emperor, died of the pandemic.4,3 Symptoms were rashes, fever, pustules, and bloody diarrhea.1,3 It is thought to be part of the factors that led to the downfall of the Roman Empire.
  • Justinian Plague: Named after Justinian 1, the Byzantine emperor at that time, the plague caused by Yersinia pestis occurred in 541 CE ravaging the Roman world and beyond.5 Hallucinations preceded other symptoms such as fever; cough fatigue; buboes in the groin, armpit, or behind the ear; lethargy, and eventual death.3,1 Between 5,000 – 10,000 people were thought to have died daily in Constantinople, and total death from the plague is estimated to be between 25 – 100 million.4,5 The emperor himself was infected, but he didn’t succumb to the plague.5 The plague resulted in food scarcity, starvation, economic instability, breakdown of law and order, and a stop in the military conquest of Rome.5,3

The Black Death: Also known simply as the Plague, it is thought to be the most fatal pandemic in human history. Originating from China in 1334, the plague spread across Europe, Asia, and Africa and was caused by the bacterium Yersinia pestis.6,1 Symptoms included fever, chills, fatigue, vomiting, buboes.2 The Plague is thought to have claimed 75 – 200 million lives and wiped out about 30% of Europe’s population. 2,4,1 Economic instability, the emergence of the middle class, the breakdown of law and order, antisemitism, turmoil, widespread destruction, food scarcity, and starvation were some of the aftermaths of the plague.6

history of global pandemics and epidemics slider 2
Depiction of the 17th-century plague in Italy at the Museo Storico Nazionale Dell’Arte Sanitaria in Rome. C: De Agostini/Getty

New World and Eurasia Pandemics

The European exploration of the Americas known as the Columbian Exchange resulted in the exchange of more than just food, animals, plants, ideas, and population. Disease exchange was another important tradeoff. Prior to the invasion by the Europeans, the Native Americans had no contact with diseases that affected Eurasia such as smallpox, whooping cough, malaria, influenza, typhus, diphtheria, and chickenpox, hence; they had no immunity to the diseases.7,8 

In the years after the exploration, these diseases became epidemic in the New World (The Americas). The mortality rate in various villages, cities, and towns was as high as 80%, and 90%, and in some cases, entire populations such as the Taino people were wiped out and became virtually extinct.8

The massive loss of human lives led to disruption in ecosystem as forests grew rapidly and animals increased.9 Economically, labour shortage ensued and also led to the Transatlantic Slave Trade establishment.9

history of global pandemics and epidemics slider 3

Industrial Revolution and Pandemics in the Modernization Process

The 18th, 19th, and 20th centuries heralded huge development in industrialization, modernization, and technological advancement. Rise in infectious diseases, and resultant pandemics and epidemics were also part of this development. Notable among these are the cholera pandemic, the Spanish flu, and the Asian Flu. 

Asian Flu: This was caused by the H2N2 influenza virus in 1957 which originated from China.4 It spread to the United States of America, Hong Kong, England, Scotland, and Singapore within months.1, 4,11 The estimated death toll during the pandemic is between 1 – 2 million. 1,4,11 

The Seven Cholera Pandemics: Caused by the bacterium Vibrio cholera, and spread through the fecal-oral route, the cholera pandemic was formerly endemic to Asia until 1817 when it spread from India to other parts of the world in what is known as the first cholera pandemic.2,10 Advancements in transportation systems aided it’s rapid spread. Subsequently, five other cholera pandemics occurred between 1827 to 1923. During the third cholera pandemic, the physician John Snow was able to trace the source of the outbreak to contaminated public water2. The seventh cholera pandemic began in 1961, and it is thought to be ongoing.1 The cholera pandemic led to sanitation emerging as a public health measure.2, 10

The Spanish Flu: The 1918 Spanish flu pandemic started in Kansas and was spread by troops.1 The H1N1 of avian origin was the cause of the Spanish flu, and symptoms were cough, fever, weakness, malaise, and nose bleeding in some mild and severe cases.1, 3 Personal hygiene and quarantine were the major public prevention health measures put in place during the pandemic.1 

Asian Flu: This was caused by the H2N2 influenza virus in 1957 which originated from China.4 It spread to the United States of America, Hong Kong, England, Scotland, and Singapore within months.1, 4,11 The estimated death toll during the pandemic is between 1 – 2 million. 1,4,11

Global Pandemics and Epidemics in the Modern Era

In modern times, pandemics and epidemics still continue to be a big part of our lives. Viruses majorly affecting the respiratory system have led to several epidemics and pandemics in the modern era. The HIV/AIDS pandemic is also another modern pandemic that humans still grapple with. 

  • The HIV/AIDS pandemic: In the 1980s, scientists first discovered the Human Immunodeficiency Virus (HIV) in the United States of America.3 It spreads through contact with body fluid such as blood, and breast milk, and through sexual intercourse and from an infected mother to her unborn child.11 HIV attacks and weakens the immune system, especially as it progresses to AIDS (Acquired Immune Deficiency Syndrome) if left untreated.11 The HIV/AIDS pandemic affects people across countries and populations, and it is more prevalent in Sub-Saharan African countries. Worldwide, HIV is thought to affect about 40 million people.3,11 It is one of the pandemics that has received widespread attention from local, regional, and global public health institutions and pharmaceutical companies in terms of research, funding, and treatment.1
  • SARS: The Severe Acute Respiratory Syndrome (SARS) was caused by the severe acute respiratory syndrome coronavirus (SARS CoV), and it originated in China in 2003 spreading to 29 countries.1,2 Case identification, contact tracing, isolation, and surveillance were the public health measures used in containing the spread of the pandemic.1
  • MERS: Middle East Respiratory Syndrome (MERS) was caused by the Middle East Respiratory Syndrome Coronavirus (MERS CoV) which was first reported in Saudi Arabia.1,2 Symptoms include cough, sore throat, fever, and chills and those above 65 years are more likely to have severe disease.2

COVID-19 Pandemic: New Pandemic Challenge of The 21st Century

Spreading from Wuhan, China to the rest of the world faster than earlier pandemics, the COVID-19 pandemic showed how swiftly pandemics can spread in this era owing to improvements in transportation, technology, and globalization. The COVID-19 pandemic is caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The Coronaviruses belong to the family Coronaviridae, and there are four genera which are alpha, beta, gamma, and delta. The SARS CoV, MERS CoV and the SARS-CoV-2 are all in the beta-coronavirus genera.2 
Dry cough, fever, fatigue, malaise, rhinorrhea, headache, shortness of breath, nausea, vomiting, diarrhea, and loss of sense of smell (anosmia) were some of the symptoms of the pandemic. 1,2,4 The COVID-19 pandemic led to a lot of public health measures. Isolation, quarantine, physical distancing, use of face masks, appropriate coughing etiquette, case identification, contact tracing, border closure, closure of public gathering sites, stay-at-home orders, movement, and transport restrictions were measures put in place by different countries to curb the pandemic. 2,11 Subsequently, vaccines were also produced and approved for use.

Social, Economic, and Political Impact of Epidemic Diseases

Pandemics and Epidemics are known for the enormous disruption they wreck on every life facet. Some of the impacts include:

Death, loss, and grief: High mortality rate means that survivors might be thrown into grief and survivor’s guilt. Distress could also set in.1,2,3

Financial and Economic Impact: Labour shortages when death tolls are high during pandemics have been recorded. Starvation and food scarcity are also economical effects of pandemics. 1,10 During the COVID-19 pandemic, public health measures put in place such as restricted movement; lockdowns; closure of public gathering centers such as schools, and religious institutions; and border closures; affected trade, livelihood, and the economy. 2,4,5

Social Impact: The breakdown of law and order was associated with earlier pandemics.1,3 Physical distancing during the COVID-19 pandemic restricted movement and social gatherings.2

Political Impact: Social unrest could also lead to political instability. For example, the Antonine Plague is thought to be one of the factors that led to the downfall of the Roman Empire.1,3 

The burden on the healthcare sector: The healthcare system takes a huge toll during pandemics. Healthcare workers become overburdened, equipment is used rapidly and needs to be produced just as fast, and medical ethics dilemmas set in.1

Global Responses and Preventive Strategies Against Pandemics

Strategies to prevent pandemics have emerged in the face of combating them. During the Black Death, quarantine surfaced as a means of curbing the pandemic.1,2,3 Also, the Cholera pandemic led to the public health prevention measure of Sanitation.1,2,3 The COVID-19 pandemic led to increased global preparedness for pandemics. Vaccination is another key preventive measure pandemics have brought about. The SARS-CoV pandemic utilized contact tracing, isolation, surveillance, and personal hygiene.1, 2The COVID-19 pandemic saw public health and pharmaceutical companies on their toes as vaccine, medication, and public health measures to curb the pandemic were put in place.1,2,3, 11
Lessons Learned From Pandemics Throughout History

Man’s disruption of ecological strata, climate change, and increased contact between humans and animals have been found culpable in pandemics.1,2,3,11 Also, globalization aids the rapid spread of diseases.10 Preventive measures such as hygiene, use of masks, and cough etiquette have been learned and continue to stay relevant.1,2,3,11

Global health surveillance of new infections has also received a lot of attention. Strategies for curbing spread such as quarantine, border closure, movement restriction, case identification, and tracing have also been learned.1,2,3,4,11 Institutions globally are now paying more attention to public health. More funding, research, and commitment are given to the health sector. The pharmaceutical industry has also rapidly evolved and become swifter in producing medications and vaccines as evidenced by the last pandemic.2,1,11

Conclusion: The Lasting Effects of Pandemics on Humanity

Pandemics, especially the last one have heightened and tightened public health measures and reminded everyone that a pandemic is never far away.1,2 Global health institutions and pharmaceutical companies have seen a lot of improvement in dealing with pandemics as the COVID-19 early vaccine production and strict public health measures showed.1,2,3,4 Preparation for the next pandemic is given to every individual, country, health institution, pharmaceutical sector, and global health institution. 

References

  1. Sampath S, Khedr A, Qamar S, Tekin A, Singh R, Green R, Kashyap R. Pandemics throughout the history. Cureus. 2021 Sep;13(9). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525686/
  2. Piret J, Boivin G. Pandemics throughout history. Frontiers in microbiology. 2021 Jan 15;11:631736. Available from: https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2020.631736/full
  3. Huremović D. Brief history of pandemics (pandemics throughout history). Psychiatry of pandemics: a mental health response to infection outbreak. 2019:7-35. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123574/
  4. Outbreak: 10 of the worst pandemics in History – MPH Online [Internet]. MPH Online. 2021. Available from: https://www.mphonline.org/worst-pandemics-in-history/
  5. Others FBA. Plague of Justinian | Description & Facts [Internet]. Encyclopedia Britannica. 2024. Available from: https://www.britannica.com/event/plague-of-Justinian
  6. The Editors of Encyclopaedia Britannica. Black Death | Definition, Cause, Symptoms, Effects, death toll, & facts [Internet]. Encyclopedia Britannica. 2024. Available from: https://www.britannica.com/event/Black-Death/Effects-and-significance
  7. Nunn N, Qian N. The Columbian exchange: A history of disease, food, and ideas. Journal of Economic Perspectives. 2010 May 1;24(2):163-88. Available from: https://www.aeaweb.org/articles?id=10.1257/jep.24.2.163
  8. McNeill JR. Columbian Exchange | Diseases, Animals, & Plants [Internet]. Encyclopedia Britannica. 2024. Available from: https://www.britannica.com/event/Columbian-exchange
  9. NCPedIa | NCPedIa [Internet]. Available from: https://www.ncpedia.org/anchor/columbian-exchange
  10. Mackenbach JP. Health problems of industrializing societies. In: BRILL eBooks [Internet]. 2020. p. 149–216. Available from: https://brill.com/display/book/9789004429130/BP000007.xml
  11. Miller K. 6 of the Worst Pandemics in History [Internet]. Health. 2023. Available from: https://www.health.com/condition/infectious-diseases/worst-pandemics-in-history
Heated and Humidified High Flow Oxygen

What is the Role of Heated and Humidified High Flow Oxygen In Respiratory Support?

by with No Comment HFO

Generally, there are two common ways of administering oxygen therapy. One of these is the high-flow device method like air entrainment masks or non-rebreathers. While the other known as low-flow devices use nasal cannula or masks. Many a time, the high-flow nasal cannula are often administered during surgical procedures. Evidence also suggests that this humidified oxygen therapy is safer at a stand-alone surgical IMCU. 
Therefore, why is heated and humidified high-flow oxygen (HFNC) necessary for respiratory support? Continue reading to know more.

Heated and Humidified High Flow Oxygen

Understanding Heated and Humidified High-Flow Oxygen Therapy

High-flow oxygen is a respiratory therapy that supplies oxygen at a significantly higher rate. It is a medical device that usually serves as a breathing support for ICU patients. Additionally, it delivers oxygen continuously through a tube inserted into the nostrils. This ventilation supply often aids patient comfort, because they are always humidified and warmed to 37°. 

On most occasions, this therapy is mostly used to treat patients experiencing respiratory distress. Also, heated and humidified high-flow oxygen therapy is always provided if standard oxygen therapy isn’t working. Hence, it helps lessen the effort your body must expend on breathing. Apart from reducing respiration effort, it also produces slight positive pressure in the upper airways.

How Does Heated and Humidified High-Flow Oxygen Work?

Unlike conventional low-flow oxygen, HFNC delivers its maximum oxygen rate beyond 30 L/min. Also, this High-flow oxygen isn’t merely a regular nasal cannula but one that’s increased extremely. However, there are some key steps in which heated and humidified high-flow oxygen is produced. Some of these are:

  1. Oxygen Heat-Up: In most cases, HFNC always heats oxygen to the same temperature as the body. Furthermore, they often provide 37 degrees Celsius of air during inspiration.
  2. High flow of gas: Additionally, this breathing support works by providing oxygen gas (FiO2) at an elevated inflow rate. It supplies about 1.00% fiO2 at up to 60 liters per minute of flow.
  3. Provides Humidified Air: Because high-flow therapy is often administered at a high standard, the gas is always humidified. Therefore, inhaled air often contains moisture that is the same as normal air.
  4. Supplied through Device: Just like any other assisted ventilator, this ventilation support is also supplied via devices. Also, depending on the patient’s fiO2 requirement, the delivering device might be nasal cannulas or masks.
Heated and Humidified High Flow Oxygen

Indication for Using Heated and Humidified High-Flow Oxygen

Sometimes, when standard oxygen therapy fails to improve low oxygen levels, HFNC may be used. In most cases, this heated and humidified high-flow oxygen is often used to support patients experiencing respiratory distress. Nevertheless, some of the breathing issues that always indicate high-flow oxygen usage are as follows:

  • Congestive heart failure
  • Respiratory distress syndrome (RDS)
  • Non-small cell lung cancer (NSCLC)
  • Bronchial asthma
  • Bronchopneumonia
  • Pulmonary edema
  • Intensive phase of Chronic obstructive pulmonary disease (COPD)
  • Broken ribs and other types of chest trauma 
High-Flow Oxygen

Benefits of Heated and Humidified High Flow Oxygen in Respiratory Care

When compared to traditional oxygen therapy, HFNC offers numerous advantages. They are known as a heated and humidified system that enables easy flow of oxygen. In addition, the fraction of inspired oxygen (fiO2) can be regulated at an extreme inflow rate. Therefore, what are the benefits of high-flow oxygen for patients with respiratory disease?

Accurate Oxygen Distribution

In normal circumstances, the oxygen delivery rates of HFNCs are usually higher than those with traditional nasal cannulas. As a result of this, there is always a limited room air retainment. Besides, it also provides a high amount of oxygen that overcomes the patient’s peak inspiratory flow rate. Therefore, it doesn’t dilute the oxygen wished to give a patient. 

Improves Functional Residual Capacity (FRC)

By supplying a varying amount of positive pressure, high-flow therapy also affects the FRC rate. This is often determined by the placement of manometers at the posterior oropharynx. On most occasions, the readings of this pressure are not always very high during closed-mouth breathing. However, when patients open their mouths, the impact nearly disappears. Additionally, research indicates that the application of HFNC readily results in a 25% improvement in FRC.

Dead space Clearance

Additionally, with heated and humidified high-flow oxygen breathing is usually more efficient. Why? This is because the continuous high oxygen flow often eliminates anatomical dead spaces present in the airways. In addition, the warm, heated air always assists with mucus and foreign particles and also reduces the energy for breathing.

Humidified Oxygen

Comparing Heated and Humidified High-Flow Oxygen to Traditional Oxygen Therapy

When comparing high-flow oxygen to traditional oxygen, several differences and similarities can be extracted. However, some following points indicate the similarities of both systems.

  1. Most of the time, both devices supply FiO2 at a variable concentration
  2. They also serve as respiratory support
  3. Neither traditional oxygen nor HFNC are delivered in the invasive mode
  4. In most cases, they are simple to administer and easily adjustable
  5. Either of the two systems can be used effectively in similar clinical conditions e.g. COPD cases, acute respiratory failure etc.

Although, heated and humidified high-flow oxygen provides some similar functions to traditional oxygen. Hence, this high-flow device also has some specialty when compared to the low-flow. Some of these significant features are:

  1. The ability to provide oxygen gas at a very high rate that ranges between 30 to 60 L/min
  2. Capacity to actively moisturize inflow air
  3. Provision warm oxygen that complies with body temperature
  4. Prevent airway problems and complications by maintaining and clearing respiratory dead spaces
  5. HFNC is also more effective at improving oxygenation, especially in hypoxemic patients.

Considerations for Implementing Heated and Humidified High-Flow Oxygen

Normally, heated and humidified high-flow oxygen is easy to use. Nonetheless, some integral factors must be considered while implementing this device. Hence, I would like to give you some basic “DEDEVUS” processes that must be considered while using HFNC.

  • Determine your patient condition and device compliance rate
  • Ensure a proper setting of the system: You must make sure the high-flow device is in good form. Additionally, thighs like the flow rate, FiO2 level, filter, battery, and ventilation slot should be examined thoroughly.
  • Don’t place a patient on high-flow oxygen immediately after the device is turned on.
  • Examine your oxygenation channels: It’s very important to verify the O2 tube connection and adjust flow to prevent FiO2 delay and regulate the flowmeter. In addition, ensure to set your internal alarm menu and avoid smoking.
  • Verify humidification supply: Things like sterile water, plastic bags, and caps should be checked thoroughly. Also, the water bag must not be empty and the permeable circuit must be monitored at every interval.
  • Use the appropriate tube and cannula with the correct placement
  • Set alarm 

Future Directions and Innovations in Heated and Humidified High-Flow Oxygen Technology

In the modern world, almost every aspect of life is gradually evolving. Some of these have led to several innovative improvements in the medical world and assisted ventilation to be precise. Hence, heated and humidified high-flow oxygen isn’t left aside. Also, most scientists believe they are one of the best and most dynamic mechanical ventilation systems. Therefore what are high-flow oxygen future trends? 

Be informed that several innovative directions of HFNC are yet to be seen. However, some of these potential features and trends, such as precise delivery, flexibility, patient compliance, personalized treatment, etc are expected to emerge soon.

Biosys Biomedical: A Reliable Respiratory Support

Heated and humidified high-flow oxygen therapy is a modern method that provides a great deal of warmed and moisturized oxygen. It is a special device with significant advantages that plays a key role in patient outcomes. Additionally, this system is a breathing support that requires proper examination before implementation as it differs from traditional oxygen therapy. Above all, it’s also a ventilation system with diverse emerging future directions. 

However, high-flow oxygen is a medical therapy that requires professionalism. So, if you are looking for a reliable source of respiratory support, you can reach out to Biosys Biomedical today. With no more ado, schedule an appointment for effective HFNC support today!

References

https://tsaco.bmj.com/content/3/1/e000179

https://www.accjournal.org/journal/view.php?doi=10.4266/acc.2021.01571 

https://www.svhlunghealth.com.au/procedures/procedures-treatments/high-flow-oxygen-therapy 

https://rebelem.com/high-flow-nasal-cannula-hfnc-part-1-how-it-works/ 

https://www.medmastery.com/guides/noninvasive-ventilation-clinical-guide/how-does-high-flow-nasal-cannula-hfnc-work 

https://ejb.springeropen.com/articles/10.4103/1687-8426.211399 

https://clinmedjournals.org/articles/ijccem/international-journal-of-critical-care-and-emergency-medicine-ijccem-4-048.php?jid=ijccem#:~:text=  

https://www.biosysmed.com/innovative-approaches-high-flow-oxygen-therapy-in-the-icu/